UDP glucuronosyltransferase 1 family, polypeptide A1
UGT-1A is a uridine diphosphate glucuronosyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small lipophilic (fat-soluble) molecules, such as steroids, bilirubin, hormones, and …
UDP-glucuronosyltransferases: Structure, Function and Drug …
UDP-glucuronosyltransferases (UGTs) are important phase II metabolic enzymes responsible for approximately 40-70% of endo and xenobiotic reactions. It catalyzes the transfer of glucuronic acid to lipophilic substrates, converting them into hydrophilic compounds that are excreted.
UGT1A1 Gene - UDP Glucuronosyltransferase Family 1 Member A1
2024年10月2日 · UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1) is a Protein Coding gene. Diseases associated with UGT1A1 include Crigler-Najjar Syndrome, Type I and Crigler-Najjar Syndrome, Type Ii. Among its related pathways are Drug ADME and Metapathway biotransformation Phase I and II.
UGT1A1 UDP glucuronosyltransferase family 1 member A1
6 天之前 · This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.
UGT1A1 gene - MedlinePlus
2012年2月1日 · The UGT1A1 gene belongs to a family of genes that provide instructions for making enzymes called UDP-glucuronosyltransferases. These enzymes perform a chemical reaction called glucuronidation, in which a compound called glucuronic acid is attached (conjugated) to one of a number of different substances. The protein produced from the …
Does heterozygosity for UGT1A1 *28 convey increased risk for …
2020年9月21日 · UDP-Glycosyltransferase 1 family, polypeptide A1 (UGT1A1) encodes the critically important bilirubin glucuronosyltransferase. Certain polymorphisms in the UGT1A1 promotor will retard...
The UDP-glucuronosyltransferases: Their role in drug metabolism …
2013年6月1日 · A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3alpha,17beta-diol glucuronide
Clinical usefulness of testing for UDP glucuronosyltransferase 1 family ...
2014年6月6日 · An association between UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) polymorphisms and irinotecan-induced neutropenia has been previously reported. In this study, we assessed the clinical usefulness of testing for UGT1A1 polymorphisms prior to the initiation of irinotecan-based chemotherapy, as this remains a controversial subject.
UGT genotyping in belinostat dosing - PubMed
Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1 substrates, of which irinotecan is a widely-described example.
Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 …
2024年2月8日 · Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT. Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases.