Tau pathology in the dorsal raphe may be a prodromal indicator …
2024年8月14日 · We observed ptau-IR in the DRN of 47.37% (9/19) of control cases, which may indicate that the DRN is one of the initial regions to develop tau pathology before an AD diagnosis.
A novel structure associated with aging is augmented in the DPP6 …
2020年11月23日 · Aβ and pTau pathologies are associated with neuroinflammation characterized by activation of microglia and astrocytes and elevated levels of proinflammatory cytokines [50, 60]. In both human patients with early AD and in mouse models of AD, Aβ accumulation precedes and promotes tau pathology.
A tau dephosphorylation-targeting chimera selectively recruits …
2024年10月17日 · Abnormal accumulation of hyperphosphorylated tau (pTau) is a major cause of neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Therefore, reducing pTau holds therapeutic promise for these diseases.
P-Tau are coexpressed with NeuN in neurons and expressed …
Specimens from human donors of ocular tissues with uncontrolled IOP and glaucoma have shown the characteristic presence of abnormal tau (AT8) and phosphorylated tau (pTau), respectively.
Integrated multimodal cell atlas of Alzheimer’s disease
2024年10月14日 · Immunoreactivity to neuronal nuclear protein (NeuN-ir) was previously shown to anticorrelate with pTau pathology 42. These 11 donors had a pronounced reduction in NeuN-ir that was not due...
Clinical and biological relevance of glial fibrillary acidic protein in ...
2023年11月3日 · Our findings indicate that GFAP is of potential clinical utility in screening amyloid pathology and predicting future cognitive decline. GFAP, NfL, and ptau-181 were moderately associated with each other, with discrepant relevance to age, sex, and AD genetic risk, suggesting their relevant but differential roles for AD assessment.
Genetic ablation of Sarm1 attenuates expression and …
2023年12月20日 · We conducted serial neurological assessments followed by histological analyses (NeuN, MBP, Iba-1, GFAP, pTDP-43, and AT8) at 1 month after rTBI. Genetic ablation of the Sarm1 gene attenuated the expression and mislocalization of phosphorylated TDP-43 (pTDP-43) and accumulation of pTau.
Diagnostic value of serum versus plasma phospho-tau for …
2022年5月11日 · Blood phosphorylated tau (p-tau) forms are promising Alzheimer’s disease (AD) biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (EDTA) plasma is limited. Firstly, we assessed the diagnostic potential of p-tau231 and p-tau181 in paired plasma and serum samples.
Differential roles of Aβ42/40, p-tau231 and p-tau217 for ... - Nature
2022年12月1日 · 146 Citations. 274 Altmetric. Metrics. Abstract. Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive...
P-tau217 correlates with neurodegeneration in Alzheimer’s …
2024年3月20日 · (D–F) IF analysis of neuronal nuclear antigen (NeuN) staining in HIP and Pir of antibody-treated mice. n = 5–6 mice for WT-IgG, n = 7 mice for PS19-IgG, and n = 7 mice for PS19-mAb2A7.