Lessons from inducible pluripotent stem cell models on neuronal ...
2024年3月1日 · Here, we review the evidence of cellular senescence in neuronal aging and disease, discuss human pluripotent stem cell-based model systems used to investigate neuronal senescence and...
Strategies for modeling aging and age-related diseases | npj Aging …
2024年7月10日 · The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and age-related diseases like Parkinson’s, and...
Cellular reprogramming as a tool to model human aging in a dish
2024年2月28日 · In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related...
Induced pluripotent stem cells, a giant leap for mankind …
Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging. A major advantage of human iPSC, compared to the pluripotent embryonic stem cells, is that they can be generated from virtually any embryonic or adult ...
Reprogramming: Emerging Strategies to Rejuvenate Aging Cells …
Therefore, human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs), nuclear transfer stem cells (ntSCs) and induced pluripotent stem cells (iPSCs) emerged as tools to model both age-associated pathologies and tissue deterioration: from 2D cell culture to 3D complex reconstructed tissues, through organoids, and cells or ...
A longevity‐specific bank of induced pluripotent stem cells from ...
2024年9月25日 · Induced pluripotent stem cells (iPSCs) faithfully capture the genetic background of the person from whom they are created and are revolutionizing pre-clinical drug screening by exhibiting the power of precision medicine.
A longevity-specific bank of induced pluripotent stem cells from ...
2024年9月25日 · Isolated peripheral blood mononuclear cells (PBMCs) from 20 of these subjects were then successfully reprogrammed into high-quality induced pluripotent stem cell (iPSC) lines which were functionally characterized for pluripotency, genomic stability, and the ability to undergo directed differentiation.
Pluripotent stem cell strategies for rebuilding the human brain
2022年11月1日 · In this review, we cover advances in methods used to differentiate human pluripotent stem cells into several highly specialized types of neurons, including cholinergic, dopaminergic, and motor neurons, and the potential clinical applications of stem cell-derived neurons for common neurodegenerative diseases, including Alzheimer’s disease ...
Stem cell aging: mechanisms, regulators and therapeutic …
Induced expression of PAX7 and exposure to defined chemical cocktails 145–147 in human pluripotent stem cells has been shown to generate engraftable muscle progenitor cells that replenish the satellite cell compartment and sustain formation of dystrophin-positive myofibers in dystrophin-deficient mice 145,147.
iPSC technology to study human aging and aging-related disorders
2012年12月1日 · Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies …