Therapeutic peptides: current applications and future directions
2022年2月14日 · A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug...
Peptides - DrugBank Online
A drug indicated to treat obesity caused by genetic POMC, PCSK1, or LEPR deficiencies or Bardet-Biedl syndrome. Angiotensin II: A peptide hormone of the RAAS system used to raise blood pressure in septic or other forms of shock. Vosoritide: An analogue of C-type naturietic peptide used to promote bone growth in pediatric patients with ...
THPdb: Database of FDA-approved peptide and protein …
2017年7月31日 · The current version of THPdb holds a total of 852 entries providing information on 239 US-FDA approved peptide and protein drugs and their 380 drug variants. Corresponding drug variants of therapeutic proteins and peptides were classified on the basis of a classification presented by Leader et al.
THPdb: Database of FDA-approved peptide and protein therapeutics
2017年7月31日 · The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance ...
Trends in peptide drug discovery - Nature Reviews Drug Discovery
2021年2月3日 · At present, there are around 80 peptide drugs on the global market, and research into new peptide therapeutics continues at a steady pace, with more than 150 peptides in clinical...
2021 FDA TIDES (Peptides and Oligonucleotides) Harvest - PMC
A total of eight peptides, two oligonucleotides, and two ADCs containing peptides out of fifty drugs have been approved by the FDA during 2021. The continuous approval of TIDES reflects the importance of this class of drugs, which offer high specificity, …
Peptide Therapeutics 2.0 - PMC - National Center for …
2020年5月13日 · Oncology, with five drugs (two radio peptides and two ADCs), metabolism (three), and endocrinology (two) are the most frequent medical indications for peptides. However, cardiovascular conditions, gastroenterology, bone diseases, dermatology, and sexual dysfunction are also targeted by peptides.
Peptide-based drug discovery: Current status and recent advances
2023年2月1日 · Diverse emerging technologies, such as DNA-encoded libraries (DELs) and display techniques, are changing the status quo in the discovery of peptide therapeutics. In this review, we analyzed US Food and Drug Administration (FDA)-approved peptide drugs and those in clinical trials, highlighting recent advances in peptide-based drug discovery.
Therapeutic peptides: Historical perspectives, current …
2018年6月1日 · To date, over 60 peptide drugs have been approved in the United States, Europe, and Japan; over 150 are in active clinical development, and an additional 260 have been tested in human clinical trials. Here we review the characteristics of peptide drugs and clinical candidates, therapeutic applications, and prospects for the future.
Therapeutic peptides: current applications and future directions
A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug discovery, production, and modification, and their current applications.