Leptin Interaction with Brain Orexigenic and Anorexigenic Pathways
2014年10月12日 · The adipocyte hormone leptin exerts anorexigenic effects by acting on brain circuits that regulate food intake and energy expenditure. Our understanding of the …
Physiology, Leptin - StatPearls - NCBI Bookshelf
2023年4月10日 · It contains orexigenic agouti-related protein/neuropeptide Y-containing (AgRP/NPY) neurons and anorexigenic proopiomelanocortin-containing (POMC) neurons. …
Network of hypothalamic neurons that control appetite - PMC
Indeed, the activity of POMC and NPY/AgRP neurons is modulated by multiple neurotransmitters and/or hormones. For instance, the anorexigenic effects of serotonin and the adipocyte …
Leptin signaling and its central role in energy homeostasis
Numerous molecules have been discovered to play essential roles in regulating the JAK2-STAT3 pathway, which influences various aspects of energy balance and sensitivity to leptin. …
Physiology of leptin: energy homeostasis, neuroendocrine function …
In the arcuate nucleus (ARC), leptin interacts with a complex neural circuit to control food intake, activating anorexigenic neurons that synthesize pro-opiomelanocortin (POMC) and cocaine- …
Leptin signalling pathways in hypothalamic neurons
2016年1月19日 · The signaling pathways known to mediate the actions of leptin include JAK–STAT signaling, PI3K–Akt–FoxO1 signaling, SHP2–ERK signaling, AMPK signaling, and …
Physiology of leptin: energy homeostasis, neuroendocrine function …
2015年1月1日 · The binding of leptin to LepRb activates several signaling pathways, including Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3), insulin …
The cellular and molecular bases of leptin and ghrelin ... - Nature
2017年2月24日 · In ex vivo hypothalamic organotypic cultures, elevated levels of cAMP were found to impair the signalling cascades that are activated by leptin, including STAT3 and S6K …
Leptin, the brain and energy homeostasis: From an apparently …
2021年4月6日 · By activating the JAK2-STAT3 pathway, leptin inhibits the orexigenic NPY/AgRP neurons whereas activates the anorexigenic POMC neurons which produce α-melanocyte …
Leptin signaling in the hypothalamus: emphasis on energy …
2003年12月1日 · It is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and …