Nova1 is a master regulator of alternative splicing in pancreatic …
Oct 10, 2014 · Apoptosis secondary to Nova1 KD, with or without concomitant exposure to pro-inflammatory cytokines, was mediated by the intrinsic (mitochondrial) pathway of apoptosis, as suggested by increased cleavage of caspases 9 and 3 …
RBM4–Nova1–SRSF6 splicing cascade modulates the
Nov 1, 2016 · RBM4a manipulated the relative levels of Nova1 spliced variants which exerted a differentially repressive effect on SRSF6 expression through the AS-coupled nonsense-mediated decay (NMD) mechanism. The splicing cascade consisting of RBM4a, Nova1, and SRSF6 constituted a novel mechanism involved in BA development. 2.
NOVA1 prevents overactivation of the unfolded protein response …
Jul 7, 2023 · NOVA1 knockdown leads to the significant down-regulation of lipid metabolism genes accompanied by hyperactivation of the unfolded protein response (UPR). Integrating CLIP-seq and RNA-seq data, we identified a repertoire of NOVA1–RNA interactions and the regulated RNA splicing or expression in the process of human adipogenesis.
Reintroduction of the archaic variant of NOVA1 in cortical …
Feb 12, 2021 · NOVA1 archaic variant in cortical organoids affects cellular, molecular, and neural network activity profiles. During human evolution, modern humans acquired a specific nucleotide substitution in the RNA binding domain of NOVA1.
NOVA1 regulates hTERT splicing and cell growth in non-small
Aug 6, 2018 · To determine if expression of NOVA1 in a NOVA1-negative cancer cell line promotes hTERT FL splicing and increases in telomerase activity, we transduced Calu6 cells with a lentiviral vector ...
NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes ...
Dec 19, 2018 · In this report, we build upon our model that NOVA1 regulates hTERT splicing by acting in conjunction with another splicing factor, PTBP1, in cancer cells to enhance the production of FL hTERT ...
NOVA1 gene information - The Human Protein Atlas
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer.
Alternative Splicing by NOVA Factors: From Gene Expression …
May 30, 2020 · In vessel endothelial cells, NOVA2 is essential for angiogenesis, while in adipocytes, NOVA1 contributes to regulation of thermogenesis and obesity. In many cancers NOVA1 and also NOVA2, by interacting with specific miRNAs and by additional mechanisms, activate oncogenic roles promoting cell proliferation, colony formation, migration, and invasion.
Nova-1 Regulates Neuron-Specific Alternative Splicing and Is …
We have combined biochemical and genetic approaches to demonstrate that Nova-1 functions to regulate alternative splicing in neurons and found that the absence of Nova-1 leads to neuronal death in spinal and brainstem neurons.
(PDF) Nova1 is a master regulator of alternative ... - ResearchGate
Sep 23, 2014 · Nova1 regulates insulin secretion and voltage-dependent current influx. INS-1E cells (A, D, E) and INS-1 832/13 cells (B–C) were transfected with siCTL or siNova1.