Nitroglycerin - StatPearls - NCBI Bookshelf
Jul 31, 2023 · Summarize the mechanism of action of nitroglycerin. Outline nitroglycerin's adverse event profile. Describe interprofessional team strategies for improving care coordination and communication to properly use nitroglycerin to improve patient outcomes in the varied scenarios where it can be effective.
Nitroglycerin: Uses, Interactions, Mechanism of Action
Mechanism of action. Nitroglycerin is converted by mitochondrial aldehyde dehydrogenase in smooth muscle cells to nitric oxide (NO), a potent vasodilator.
Nitroglycerin - Wikipedia
At low doses, nitroglycerin dilates veins more than arteries, thereby reducing preload (volume of blood in the heart after filling); this is thought to be its primary mechanism of action. By decreasing preload, the heart has less blood to pump, which decreases oxygen requirement since the heart does not have to work as hard.
Nitroglycerin (medication) - Wikipedia
Nitroglycerin, also known as glyceryl trinitrate (GTN), is a vasodilator used for heart failure, high blood pressure (hypertension), anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart or due to the recreational use of cocaine.
Nitroglycerin - PubMed
Jul 31, 2023 · This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, monitoring, and toxicity of nitroglycerin, so providers can direct patient therapy successfully in instances where nitroglycerin benefits patient care.
Nitroglycerin: Dosage, Mechanism/Onset of Action, Half-Life
Feb 17, 2020 · Mechanism of Action. Nitroglycerin forms free radical nitric oxide. In smooth muscle, nitric oxide activates guanylate cyclase which increases guanosine 3’5’ monophosphate (cGMP) leading to dephosphorylation of myosin light chains and smooth muscle relaxation.
After 130 years, the molecular mechanism of action of nitroglycerin …
Both effects were attributed to the vasodilator action of nitroglycerin, which quickly became apparent to the physicians and physiologists in local communities. But what was the mechanism of this vasodilator action of the most powerful explosive …
After 130 years, the molecular mechanism of action of nitroglycerin …
Jun 11, 2002 · Mitochondrial aldehyde dehydrogenase purified from bovine liver showed identical catalytic properties to the mouse enzyme. Inhibitors of aldehyde dehydrogenase, such as cyanamide and chloral hydrate, blocked the formation of 1,2-glyceryl dinitrate from nitroglycerin.
The Role of Nitroglycerin and Other Nitrogen Oxides in …
In this review, we detail the discovery of nitroglycerin and its early use in the treatment of angina; the history of the discovery of nitric oxide (NO), its sources, and its roles; the mechanism of action, preparations, and hemodynamic and nonhemodynamic effects of the organic nitrates, as well as their biotransformation; and the clinical uses ...
Clinical pharmacokinetics and pharmacodynamics of glyceryl …
Abstract. This review discusses the pharmacokinetics and pharmacodynamics of glyceryl trinitrate (nitroglycerin; GTN) pertinent to clinical medicine. The pharmacokinetics of GTN associated with various dose regimens are characterised by prominent intra- and inter-individual variability.