A dynamic multi-tissue model to study human metabolism
2021年1月22日 · We developed a dynamic multi-tissue model, which recapitulates key properties of human metabolism at the molecular and physiological level based on the...
Reconstructing Kinetic Models for Dynamical Studies of Metabolism …
2022年8月30日 · Kinetic models of metabolism relate metabolic fluxes, metabolite concentrations and enzyme levels through mechanistic relations, rendering them essential for understanding,...
Metabolic Modelling as a Framework for Metabolomics Data …
Constraint-based modelling and kinetic modelling are among the most widely used methods to study cell metabolism at different scales, ranging from cells to tissues and organisms. These approaches enable integrating metabolomic data, among others, to …
An atlas of human metabolism | Science Signaling - AAAS
2020年3月24日 · Robinson et al. generated Human1, an extensively curated, genome-scale model of human metabolism that unified two parallel model lineages using an open source repository to enable rapid, trackable updates. The authors also developed Metabolic Atlas (https://www.metabolicatlas.org/), an online platform for exploring Human1.
Using mathematical models to understand metabolism, genes, and disease
2015年9月23日 · Mathematical models are a useful tool for investigating a large number of questions in metabolism, genetics, and gene–environment interactions. A model based on the underlying biology and biochemistry is a platform for in silico biological experimentation that can reveal the causal chain of events that connect variation in one quantity to ...
Kinetic modeling of metabolism: Present and future
2021年6月1日 · Kinetic models of metabolism are predictors of temporal metabolic behavior of living organisms that integrate multi-omics data sets with reaction network models to interpret reaction rates, kinetic parameters, and enzyme levels.
[PDF] The best models of metabolism - Semantic Scholar
2017年5月19日 · This article presents the metabolic modelling approaches that investigate cell metabolism at steady state, complying to the constraints imposed by mass conservation law and thermodynamics of reactions reversibility, and describes dynamic kinetic models that are based on the mathematical representation of the mechanistic description of nonlinear ...
A genome-scale metabolic model of - Nature
2021年8月9日 · Here, the authors propose a framework that allows to model eukaryotic metabolism considering gene expression and thermodynamic constraints.
A Mathematical Model of the Human Metabolic System and …
2014年8月15日 · We have developed a compartmental model of human metabolism including substrate transport and utilisation in the plasma, the liver and skeletal muscle. Our simulated results have been shown to be in good agreement with experimental data, in particular the results for plasma concentrations and hepatic glycogen.
Human Systems Biology and Metabolic Modelling: A …
2019年6月9日 · Metabolic systems biology offers powerful abstraction tools to simulate all known metabolic reactions in a cell, therefore providing a snapshot that is close to its observable phenotype. In this review, we cover the 15 years of human metabolic modelling.