Liver X receptors in lipid signalling and membrane homeostasis
2018年6月14日 · Understanding how LXRs regulate membrane composition and function might provide new therapeutic insight into diseases associated with dysregulated lipid metabolism, including atherosclerosis,...
Integrative analysis reveals multiple modes of LXR ... - PNAS
LXRs are critical regulators of hepatic metabolism and function, but their mechanisms of action at the genome level are incompletely understood. We performed integrated analysis of genome-wide chromatin accessibility, gene expression, and transcription factor binding.
Liver X receptors in lipid metabolism: opportunities for drug
2014年5月16日 · Subtype-selective LXR agonists and tissue-selective agonists are promising strategies for the development of targeted modulators of lipid metabolism. Alterations in LXR-dependent gene...
Transcriptional integration of metabolism by the nuclear sterol ...
2012年3月14日 · Liver X receptor (LXR) and farnesoid X receptor (FXR) form a heterodimer with retinoid X receptor (RXR) and mediate changes in gene expression following activation by their natural ligands,...
LXRs link metabolism to inflammation through Abca1 …
2015年7月14日 · Here we demonstrate that the ability of LXRs to repress inflammatory gene expression in cells and mice derives primarily from their ability to regulate lipid metabolism through transcriptional activation and can occur in the absence of SUMOylation.
PPAR- and LXR-dependent pathways controlling lipid metabolism and …
PPARs have been found to regulate diverse aspects of lipid metabolism, including fatty acid oxidation, fat cell development, lipoprotein metabolism, and glucose homeostasis. Intervention studies indicate that activation of PPARα, PPARγ, and LXRs by specific synthetic ligands can inhibit the development of atherosclerosis in animal models.
Transcriptional integration of metabolism by the nuclear sterol ...
Early studies indicate that activation of the LXR pathways can directly modulate glucose metabolism via effects on islet cells of the pancreas. Indeed, studies in a pancreatic β-cell line (MIN6) and in isolated human islet cells demonstrated that LXR agonists increase both basal and stimulated insulin secretion 55 , 56 .
LXRs Regulate ER Stress and Inflammation through Dynamic
2013年11月5日 · LXR activation promotes the incorporation of unsaturated fatty acids into PL through Lpcat3, thereby reducing hepatic ER stress and inflammation in the context of genetic obesity. These studies identify the LXR-Lpcat3 pathway as an important modulator of PL metabolism, metabolic stress responses, and inflammation.
Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer
2015年4月7日 · Bovenga et al. review how intracellular cholesterol levels and activation of the nuclear receptor LXR can be uncoupled during cell proliferation and discuss the therapeutic potential of targeting cancer cell metabolism via pharmacological modulation of LXR activity.
LXR-Dependent Gene Expression Is Important for Macrophage Survival and ...
2004年10月15日 · The liver X receptors (LXRs) are nuclear receptors with established roles in the regulation of lipid metabolism. We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses. Mice lacking LXRs are highly susceptible to infection with the intracellular bacteria Listeria ...
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