Integrins: An Overview of Structural and Functional Aspects
Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion. 1 With their extracellular head region, most integrins bind extracellular matrix (ECM) glycoproteins such as laminins and collagens in basement membranes or connective tissue components like fibronectin. Others bind counterreceptors on neighboring cells, bacterial ...
Targeting integrin pathways: mechanisms and advances in …
2023年1月2日 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and...
Integrins - Molecular Biology of the Cell - NCBI Bookshelf
Integrins are the principal receptors used by animal cells to bind to the extracellular matrix. They are heterodimers and function as transmembrane linkers between the extracellular matrix and the actin cytoskeleton. A cell can regulate the adhesive activity of its integrins from within.
The role of integrins in inflammation and angiogenesis
2020年10月7日 · Integrins play a key role in cell proliferation, tissue repair, inflammation, infection, and angiogenesis. This review summarizes current evidence from human and animal studies on integrin ...
Integrin adhesion complexes: Current Biology - Cell Press
2021年5月24日 · Integrin-mediated cell adhesion is regulated at multiple levels. These include the regulation of integrin expression, ligand availability, heterodimer specificity and activity, and the recruitment of different intracellular proteins.
Organization, dynamics and mechanoregulation of integrin
2022年9月27日 · Integrin adhesion complexes (IACs) are highly dynamic and one of their key features is their ability to transduce and respond to mechanical forces.
Integrin signalling and function in immune cells - PMC
Integrins not only mediate cell–cell and cell–extracellular matrix adhesion, but also affect the multitude of signal transduction cascades in control of cell survival, proliferation, differentiation and organ development.
Structural and mechanical functions of integrins - PMC
2013年10月8日 · Integrins are ubiquitously expressed cell surface receptors that play a critical role in regulating the interaction between a cell and its microenvironment to control cell fate. These molecules are regulated either via their expression on the cell surface or through a unique bidirectional signalling mechanism.
Integrins - PubMed
Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. The integrin family is composed of 24 alphabeta heterodimeric members that mediate the attachment of cells to …
Integrins in Health and Disease | New England Journal of Medicine
2022年9月28日 · Dr. Hynes coined the term “integrin” for these wonderfully complicated molecules that “integrate” the extracellular matrix with the intracellular environment (the cytoskeleton, in particular).
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