The biology and management of systemic anaplastic large cell lymphoma
2015年7月2日 · Systemic anaplastic large cell lymphoma (ALCL) is an aggressive CD30 + non-Hodgkin lymphoma. Anaplastic lymphoma kinase–positive (ALK+) ALCL is associated with the NPM-ALK t(2;5) translocation, which is highly correlated with the identification of the ALK protein by immunohistochemistry. ALK+ ALCL typically occurs in younger patients and has ...
Anaplastic Large Cell Lymphoma - StatPearls - NCBI Bookshelf
2023年7月3日 · Objectives: Review the etiology and epidemiology of ALK+ ALCL. Describe the histopathology and clinical presentation of ALK+ ALCL. Summarize the treatment and prognosis of ALK+ ALCL. Discuss modalities to improve care coordination among interprofessional team members in order to improve outcomes for patients affected by ALK+ ALCL.
Pathobiology of Anaplastic Large Cell Lymphoma - PMC
2011年2月6日 · According to the WHO classification, ALCL is not sustained by a unique histotype but actually includes five morphologic variants (common, giant cell-rich, lympho-histiocytic, small-cell type, and Hodgkin-like) [ 1, 2, 13, 14 ]. Indeed, common ALCL corresponds to the description of the tumor given by Stein and coworkers in 1985 [ 3 ].
Anaplastic large cell lymphoma: pathology, genetics, and clinical ...
Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30.
Anaplastic Large Cell Lymphoma: Contemporary Concepts and …
2018年12月31日 · While histologic features of ALCL subtypes have significant overlap, genomic studies suggest the unique pathophysiology and molecular events of tumorigenesis. As a group, ALCLs are rare among non-Hodgkin lymphomas comprising 1–3% overall.
Primary Cutaneous Anaplastic Large Cell Lymphoma—A Review …
Histologically, primary cutaneous ALCL consists of a diffuse dermal infiltrate of medium to large anaplastic/pleomorphic cells with abundant amphophilic-to-eosinophilic cytoplasm, horseshoe-shaped nuclei, strong and diffuse expression of CD30, and with focal or no epidermotropism.
Anaplastic Large Cell Lymphoma: The Shifting Sands of …
2001年3月1日 · ALCL was first recognized based on characteristic histologic features (sinusoidal invasion) and a distinctive immunophenotype (CD30+) (Fig. 1) (1). However, neither sinusoidal invasion nor...
The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL)
2018年4月4日 · ALCL was recognized for the first time by Stein et al. in 1985 as “anaplastic large cell Ki-1-positive lymphomas”; an aggressive non-Hodgkin’s lymphoma (NHL) exhibiting a morphology suggestive of “malignant histiocytosis” (MH), but with immunohistochemical features overlapping with those of classic Hodgkin’s lymphoma (CHL).
Article Anaplastic Large Cell Lymphoma: The Shifting Sands of ...
2001年3月1日 · ALCL was first recognized based on characteristic histologic features (sinusoidal invasion) and a distinctive immunophenotype (CD30+). However, neither sinusoidal invasion nor CD30-positivity proved to be entirely specific.
Anaplastic large cell lymphoma: pathological, molecular and …
The large anaplastic cells rosetting around a blood vessel (asterisk) show ALK protein expression in both the cytoplasm and the nucleus (arrowhead). In the smaller cells, ALK labelling is restricted to the nucleus (arrow) (lymph node paraffin section; monoclonal antibody ALKc; …