Can the salt form of my organic compound be determined using NMR?
In the 1 H NMR spectrum of an ammonium chloride salt (R 1 R 2 R 3 N HCl or R 1 R 2 R 3 HN + Cl-), you will observe a signal for the ammonium proton (+ N-H ) which will be absent in the 1 H...
High-Field Chlorine NMR Spectroscopy of Solid Organic Hydrochloride ...
2001年10月18日 · A series of organic hydrochloride salts has been investigated using solid-state 35 Cl and 37 Cl NMR spectroscopy at applied magnetic field strengths of 9.4 and 18.8 T. Magic-angle spinning, static Hahn-echo, and quadrupolar Carr−Purcell Meiboom−Gill (QCPMG) echo experiments have been applied to investigate the chlorine electric field ...
35Cl solid-state NMR of HCl salts of active pharmaceutical …
A series of HCl salts of active pharmaceutical ingredients (APIs) have been characterized via35Cl solid-state NMR (SSNMR) spectroscopy and first-principles plane-wave density functional theory (DFT) calculations of 35Cl NMR interaction tensors. 35Cl NMR spectra have been acquired at both standard (9.4 T) and International Year of ...
Two-dimensional proton-detected 35Cl/1H correlation solid-state NMR …
2016年1月26日 · The determination of structure of hydrochloride salts of active pharmaceutical ingredients (HCl APIs) utilizing 35 Cl solid-state NMR studies has been of considerable interest in the recent past.
35Cl solid-state NMR spectroscopy of HCl pharmaceuticals and …
Herein, we demonstrate the use of 35 Cl solid-state NMR (SSNMR) at moderate (9.4 T) and high (21.1 T) magnetic field strengths for the structural fingerprinting of hydrochloride (HCl) salts of active pharmaceutical ingredients (APIs) and several polymorphs, in both bulk and dosage forms.
Magnetic Resonance in Chemistry - Analytical Science Journals
2021年7月1日 · Heteronuclear multiple-quantum coherence (HMQC) pulse sequences for establishing heteronuclear correlation in solid-state nuclear magnetic resonance (NMR) between 35 Cl and 1 H nuclei in chloride salts under fast (60 kHz) magic-angle spinning (MAS) and at high magnetic field (a 1 H Larmor frequency of 850 MHz) are investigated.
High-Field Chlorine NMR Spectroscopy of Solid Organic Hydrochloride …
2001年10月18日 · A series of organic hydrochloride salts has been investigated using solid-state 35 Cl and 37 Cl NMR spectroscopy at applied magnetic field strengths of 9.4 and 18.8 T. Magic-angle spinning,...
[PDF] 35Cl solid-state NMR of HCl salts of active pharmaceutical ...
2014年7月16日 · A series of HCl salts of active pharmaceutical ingredients (APIs) have been characterized via35Cl solid-state NMR (SSNMR) spectroscopy and first-principles plane-wave density functional theory (DFT) calculations of 35Cl NMR interaction tensors. 35Cl NMR spectra have been acquired at both standard (9.4 T) and high (21.1 T) magnetic field ...
Pharmaceutical salts: Theory, use in solid dosage forms and in …
2016年12月1日 · For I and II, which were received as HCl salts, the material was dissolved in 0.1 M HCl and titrated with additional concentrated HCl until a solution was obtained. A volume of sodium hydroxide (ca 24 mM) was added such that there was an excess of hydroxide ions relative to the estimated hydrogen ions in the sample.
(PDF) 35Cl solid-state NMR of HCl salts of active pharmaceutical ...
2014年8月21日 · A series of HCl salts of active pharmaceutical ingredients (APIs) have been characterized via35Cl solid-state NMR (SSNMR) spectroscopy and first-principles plane-wave density functional...