Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic antioxidants. Previous studies on the antioxidant efficiency of fer-1 adopted kinetic tests where a diazo compound generates the hydroperoxyl radical scavenged by the antioxidant.
OTUB1 regulation of ferroptosis and the protective role of ferrostatin …
3 天之前 · At the age of 16 weeks, the MRL/lpr mice were initiated on a treatment regimen involving intraperitoneal injections of Ferrostatin-1 at a dosage of 1 mg/kg/day . The control group received an ...
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 ...
High-throughput screening efforts have identified ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1) as potent inhibitors of ferroptosis − an activity that has been ascribed to their ability to slow the accumulation of lipid hydroperoxides.
The cell biology of ferroptosis | Nature Reviews Molecular Cell …
2024年2月16日 · Anthonymuthu, T. S. et al. Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against...
Beyond ferrostatin-1: a comprehensive review of ferroptosis …
2023年12月1日 · Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential.
Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · Ferrostatin-1 (Fer-1) was identified as a ferroptosis inhibitor by Dixon et al. in 2012, which was proved to inhibit RSL3 or erastin induced ferroptosis in HT-1080 cells.
Resolving the paradox of ferroptotic cell death: Ferrostatin-1 …
2020年10月16日 · Ferrrostatin-1 inhibits the production of pro-ferroptotic signals, 15-HpETE-PE. To directly assess the ability of Fer-1 to regulate 15-HpETE-PE production by 15LOX and its complex with PEBP1, we tested Fer-1's effects on oxidation of free ETE and ETE-PE.
Design, Synthesis, and Biological Evaluation of New Improved ...
Ferrostatin-1 (Fer-1), a first potent ferroptosis inhibitor, faces limitations in clinical use due to its low potency and metabolic instability. This study introduces a series of novel Ferrostatin-1 analogs designed to enhance plasm stability.
Ferroptosis inhibitor ferrostatin-1 attenuates morphine tolerance ...
Ferrostatin-1 and liproxstatin-1, both ferroptosis inhibitors, protect cells. Liproxstatin-1 decreases morphine tolerance. Yet, ferrostatin-1's effect on morphine tolerance remains unexplored. This study aimed to evaluate the influence of ferrostatin-1 on the advancement of morphine tolerance and understand the underlying mechanisms in male rats.
Ferrostatin-1 alleviates cytotoxicity of cobalt nanoparticles by ...
2022年2月24日 · Ferrostatin-1, a highly effective free radical trapping antioxidant (RTA) compound, has been shown to effectively inhibit ferroptosis and is associated with excellent protective efficacy across both in vivo and in vitro disease models . To date, nothing is known regarding the mechanism through which CoNPs cause ferroptosis.
Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic antioxidants. Previous studies on the antioxidant efficiency of fer-1 adopted kinetic tests where a diazo compound generates the hydroperoxyl radical scavenged by the antioxidant.
Ferrostatin-1 alleviates oxalate-induced renal tubular epithelial …
2022年6月15日 · The present study aimed to evaluate the role and mechanism of ferrostatin-1 (Fer-1) in oxalate (Ox)-induced renal tubular epithelial cell injury, fibrosis, and calcium oxalate (CaOx) stone formation. A CaOx model in mice kidneys was established via intraperitoneal injection of 80 mg/kg glyoxylic acid for 14 days.
FERROSTATIN-1-LOADED LIPOSOME TREATMENT FOR …
2024年4月8日 · This study aims to evaluate the clinical efficacy of ferrostatin-1, an inhibitor of ferroptosis, in prevention and treatment of ISR in CHD patients who received PCI treatment.
Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters ...
2024年7月1日 · Ferrostatin-1 improves cardiac function in SIRT3cKO mice by targeting mitochondrial iron-sulfur clusters and aconitase. Ferroptosis is a form of iron-regulated cell death implicated in ischemic heart disease. Our previous study revealed that Sirtuin 3 (SIRT3) is associated with ferroptosis and cardiac fibrosis.
Ferrostatin-1 | C15H22N2O2 | CID 4068248 - PubChem
Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation.
Ferrostatin-1 post-treatment attenuates acute kidney injury in …
2023年9月8日 · Ferrostatin-1, a specific ferroptosis inhibitor, has been demonstrated to prevent renal injury through ferroptosis inhibition. Methods. Utilizing a murine AKI model, we investigated the effects of Ferrostatin-1 by administering it post-injury.
Ferrostatin-1 = 95 HPLC 347174-05-4 - MilliporeSigma
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
Ferrostatin-1 - Cell Signaling Technology
Ferrostatin-1 is an antioxidant that is a potent, selective inhibitor of erastin-induced ferroptosis with an EC 50 value of 60 nM (1,2). It effectively inhibits ferroptosis in cancer cells and prevents glutamate-induced cell death in rat hippocampal brain slices.
Ferrostatin-1 Ameliorates Liver Dysfunction via Reducing Iron in ...
2022年4月12日 · Ferrostatin-1 (Fer-1) was administered intraperitoneally (2.5 μM/kg/day) starting 3 days before TAA treatment. Deferoxamine (DFO) was intraperitoneally injected (200 mg/kg/day) with TAA treatment for 3 days. We further observed the effect of Fer-1 on TAA model with high-iron diet feeding.
Ferrostatin-1 (Fer-1) | Ferroptosis Inhibitor - MedChemExpress
Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death.
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