Deamination - Wikipedia
Deamination is the removal of an amino group from a molecule. [1] Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver; however, it can also occur in the kidney.
Deaminase - an overview | ScienceDirect Topics
A deaminase is an enzyme that acts on RNA molecules by converting adenosine (A) to inosine (I) in double-stranded RNA. It contains specific domains for binding to RNA and catalyzing the deamination process. AI generated definition based on: Brenner's Encyclopedia of Genetics (Second Edition), 2001. Add to Mendeley.
Adenosine deaminase - Wikipedia
Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Its primary function in humans is the development and maintenance of the immune system. [5]
Deaminase - an overview | ScienceDirect Topics
Deamination reactions are the major types of base modification in mammals. Conversion of cytosine (C) or adenosine (A) to uracyl (U) or inosin (I), respectively, might change coding potential of mRNA (s) and result in the synthesis of protein isoform (s) not predictable from genomic DNA sequence.
18.5: Pathways of Amino Acid Degradation - Biology LibreTexts
2024年5月16日 · The catabolic path of the carbon skeletons involves simple 1-step aminotransferase reactions that directly produce net quantities of a TCA cycle intermediate. The glutamate dehydrogenase reaction operating in the direction of 2-oxoglutarate (α-ketoglutarate) production provides a second avenue leading from glutamate to gluconeogenesis.
Deamination - an overview | ScienceDirect Topics
Almost all DNA bases undergo deamination in spontaneous reactions, with the exception of thymine – which does not have an amino group. Most types of deaminations produce a base that does not naturally occur in DNA (the only exception is the deamination of 5-methylcytosine), and this facilitates the identification and excision of the ...
10.2: Amino Acids Degradation - Chemistry LibreTexts
2022年4月26日 · Generally, the first step in the breakdown of amino acids is the separation of the amino group from the carbon skeleton, usually by a transamination reaction. The carbon skeletons resulting from the deaminated amino acids are used to form either glucose or fats, or they are converted to a metabolic intermediate that can be oxidized by the ...
Discovery of deaminase functions by structure-based protein …
We showed that AlphaFold2-predicted structures classified deaminases reliably into distinct clades with diverse protein folds and catalytic functions. We built on this by identifying deaminases with novel and different DNA substrates, which in turn permits the design of bespoke precision genome editing tools.
Towards a comprehensive understanding of RNA deamination: …
2022年6月6日 · Deamination of the nucleobases in DNA and RNA is a result of spontaneous hydrolysis, endogenous or environmental factors as well as deaminase enzymes (1,2). As a result (deoxy)cytidine, (deoxy)adenosine and (deoxy)guanosine are transformed into (deoxy)uridine, (deoxy)inosine, and (deoxy)xanthosine (dX, X) and (deoxy)oxanosines (dO, O).
Deaminase deluge yields new opportunities for ... - Cell Press
2024年3月7日 · This simple chemical reaction, however, can cause profound changes in polynucleotide substrates—in RNA by changing codons, regulatory elements, structural motifs, and/or functionality and in DNA by creating pre-mutagenic lesions with both immediate and downstream consequences.