Muc1: a multifaceted oncoprotein with a key role in cancer …
Furthermore, it has been reported that MUC1 blocks hypoxia-induced cell death in colon cancer cells by mediating decreases in intracellular ROS concentration and reducing prolyl hydrolase-3 (PHD-3) activity that suppresses HIF-1α stability .
Expression of MUC1 in different tumours and its clinical …
Expression of MUC1 in colorectal cancer. Colorectal cancer is one of the most common malignancies in China, and is prone to occur in the sigmoid colon and rectum. In recent years, a number of reports have confirmed that MUC1 may be a dominant antigen for the diagnosis and targeted therapy for colorectal cancer (66,67).
MUC1-C activates the TAK1 inflammatory pathway in colon cancer
Feb 9, 2015 · The present studies demonstrate that the MUC1-C transmembrane subunit induces TAK1 expression in colon cancer cells. MUC1 also induces TAK1 in a MUC1+/−/IL-10−/− mouse model of colitis...
MUC1 and colorectal cancer pathophysiology considerations
Several lines of evidence point towards a biological role of mucin and particularly MUC1 in colorectal cancer. A positive correlation was described between mucin secretion, proliferation, invasiveness, metastasis and bad prognosis. But, the role of MUC1 in cancer progression is still controversial and somewhat confusing.
Cancer-associated hypersialylated MUC1 drives the ... - Nature
Nov 4, 2020 · Here we show that a sialylated tumour-associated glycoform of the mucin MUC1, MUC1-ST, through the engagement of Siglec-9 can specifically and independently induce the differentiation of...
MUC1: An emerging target in cancer treatment and diagnosis
Nov 1, 2022 · It was found that surface-enhanced Raman scattering nanoprobes (SERS NPs) show excellent promise in cancer imaging, using MUC1-based DNA aptamers to functionalize SERS NPs to target MUC1 in human breast cancer. MUC1-SERS NPs actively target homing to tumors via MUC1 and can be used for targeted imaging of tumor range, progression and …
MUC1 plays an essential role in tumor immunity of colorectal cancer ...
Increasing knowledge of colorectal cancer stem cells (CCSCs) and tumor microenvironment improves our understanding of cellular mechanisms involved in the immunity against colorectal cancer (CRC). Tumor associated antigens were evaluated via RNA-seq and bioinformatics analysis, evoking promising targ …
MUC1-C intersects chronic inflammation with epigenetic ... - Nature
Oct 11, 2023 · MUC1-C activates (i) the BMI1/PRC1 complex in cancer cells 55, (ii) the LGR5 stemness-associated factor in the progression of colitis to colorectal cancer 51; and (iii) NOTCH1 in TNBC, CRPC...
MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer
Jun 14, 2016 · Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for MUC1, MUC2, MUC5AC, and MUC6 expression by immunohistochemical staining, using tissue microarrays.
Development of a highly efficacious, first-in-class antibody-drug ...
Background: Poor prognosis and mortality due to metastatic colorectal cancer (mCRC) remains a stiff challenge and the management of mCRC continues to be a significant unmet medical need. An aberrantly glycosylated Mucin 1 (MUC1) is overexpressed in > 80% of CRC and development of novel approaches for targeting of MUC1 are critically needed.