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  1. Colorectal Cancer MUC1 的研究
    PubMed
    MUC1 plays an essential role in tumor immunity of colorectal cancer stem cell vaccine
    Increasing knowledge of colorectal cancer stem cells (CCSCs) and tumor microenvironment improves our understanding of cellular mechanisms involved in the immunity against colorectal cancer (CRC). Tumor associated antigens were evaluated via RNA-seq and bioinformatics analysis, evoking promising targ...
    作者: Mei Guo
    已发布: 2020/8
    Keywords: Cancer ste…
    ScienceDirect
    Original MUC1 expression in colorectal carcinoma: Clinicopathological correlation and prognostic significanceExpresión de MUC1 en el carcinoma colorectal: correlación clinicopatológica y valor pronóstico
    Introduction MUC1 overexpression has been linked to cancer development and has been associated with a higher stage at diagnosis and presence of lymph node or distant metastases. However, its prognostic significance is still unclear. We aimed to evaluate the relationship between MUC1 expression and ...
    已发布: 2018/10/01
    Cited By: 0
    Keywords: Mucin; Col…
    PubMed
    MUC1-induced immunosuppression in colon cancer can be reversed by blocking the PD1/PDL1 signaling pathway
    Mucin1 (MUC1) upregulation in colon cancer has been linked to poor patient outcomes and advanced stage at diagnosis. This is partially due to MUC1-mediated inhibition of T-cell proliferation affecting efficient lysis by cytotoxic lymphocytes, which contributes to escape from immune surveillance. In ...
    作者: Yinghui Zhang
    已发布: 2020/12
    Keywords: MUC1; PD…
    ScienceDirect
    MUC1 plays an essential role in tumor immunity of colorectal cancer stem cell vaccine
    Increasing knowledge of colorectal cancer stem cells (CCSCs) and tumor microenvironment improves our understanding of cellular mechanisms involved in the immunity against colorectal cancer (CRC). Tumor associated antigens were evaluated via RNA-seq and bioinformatics analysis, evoking promising targ...
    已发布: 2020/08/01
    Cited By: 0
    Keywords: Colorectal …
  2. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5500204

    Muc1: a multifaceted oncoprotein with a key role in cancer …

    仅显示来自 pmc.ncbi.nlm.nih.gov 的搜索结果
  3. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC97…

    Expression of MUC1 in different tumours and its clinical …

    Expression of MUC1 in colorectal cancer. Colorectal cancer is one of the most common malignancies in China, and is prone to occur in the sigmoid colon and rectum. In recent years, a number of reports have confirmed that MUC1 may …

    标记:
    Colorectal cancer
    Colon Cancer
    Muc1 Colon
    Muc1 Expression in Cancer
  5. Nature
    https://www.nature.com/articles/onc2014442

    MUC1-C activates the TAK1 inflammatory pathway in …

    2015年2月9日 · The present studies demonstrate that the MUC1-C transmembrane subunit induces TAK1 expression in colon cancer cells. MUC1 also induces TAK1 in a MUC1+/−/IL-10−/− mouse model of colitis...

    标记:
    Colorectal cancer
    Colon Cancer
    Muc1 Colon
    Muc1 Expression in Cancer
  6. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2703837

    MUC1 and colorectal cancer pathophysiology considerations

    标记:
    Colorectal cancer
    Muc1 Cancer
  7. Nature
    https://www.nature.com/articles/s42003-020-01359-5

    Cancer-associated hypersialylated MUC1 drives the ... - Nature

    标记:
    Publish Year:2020
    MUC1
  8. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0007455122003113

    MUC1: An emerging target in cancer treatment and diagnosis

  9. 其他用户还问了以下问题
    Is MUC1 a tumor?
    MUC1 is highly expressed in a variety of tumors, including breast, bladder, pancreatic and ovarian cancers, and is associated with poor prognosis , , . MUC1 plays completely different roles in normal tissues and tumors.

    MUC1: An emerging target in cancer treatment and diagnosis

    sciencedirect.com
    Does MUC1 expression correlate with prognosis of colorectal cancer?
    Hiraga Y, Tanaka S, Haruma K, et al. (1998) Immunoreactive MUC1 expression at the deepest invasive portion correlates with the prognosis of colorectal cancer. Oncology 55:307–319

    MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer

    link.springer.com
    What is tumor-associated mucin 1 (MUC1)?
    The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor-associated MUC1 differs from the MUC1 expressed in normal cells with regard to its biochemical features, cellular distribution, and function.

    Muc1: a multifaceted oncoprotein with a key role in cancer progression

    pmc.ncbi.nlm.nih.gov
    Does MUC1 block hypoxia-induced cell death in colon cancer cells?
    Furthermore, it has been reported that MUC1 blocks hypoxia-induced cell death in colon cancer cells by mediating decreases in intracellular ROS concentration and reducing prolyl hydrolase-3 (PHD-3) activity that suppresses HIF-1α stability .

    Muc1: a multifaceted oncoprotein with a key role in cancer progression

    pmc.ncbi.nlm.nih.gov
    How does MUC1 function in cancer cells?
    In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-transcriptional levels. This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1.

    Muc1: a multifaceted oncoprotein with a key role in cancer progression

    pmc.ncbi.nlm.nih.gov
    Does transmembrane mucin MUC1 overexpression affect colorectal cancer?
    Khanh DT, Mekata E, Mukaisho K-I, et al. (2013) Transmembrane mucin MUC1 overexpression and its association with CD10 + myeloid cells, TGF-β1 expression, and tumor budding grade in colorectal cancer.

    MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer

    link.springer.com
    反馈
  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/32470879

    MUC1 plays an essential role in tumor immunity of colorectal …

    标记:
    Colorectal cancer
    Muc1 Cancer
    Publish Year:2020
  11. Nature
    https://www.nature.com/articles/s42003-023-05395-9

    MUC1-C intersects chronic inflammation with epigenetic ... - Nature

    标记:
    Colorectal cancer
    Atrayee Bhattacharya
  12. Springer
    https://link.springer.com/article/10.1007/…

    MUC1, MUC2, MUC5AC, and MUC6 in colorectal …

    2016年6月14日 · Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for …

    标记:
    Colorectal cancer
    Muc1 Cancer
    Publish Year:2016
  13. ASCO Publications
    https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.e15600

    Development of a highly efficacious, first-in-class antibody-drug ...

    标记:
    Colorectal cancer
    Muc1 Cancer