Cell type–specific genetic regulation of gene expression
2020年9月11日 · Detection of cell type–specific effects on gene expression. The enrichment of seven cell types is calculated across GTEx tissues, enabling mapping of cell type–interaction QTLs for expression and splicing by testing for significant interactions between genotypes and cell type enrichments.
Inference of cell type-specific gene regulatory networks on cell ...
2023年5月27日 · Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory networks (GRNs) that connect transcription factors and signaling proteins to target genes.
AI-designed DNA sequences regulate cell-type-specific gene expression
2024年10月23日 · Researchers have used artificial-intelligence models to create regulatory DNA sequences that drive gene expression in specific cell types. Such synthetic sequences could be used to target...
Cell type-specific inference of differential expression in spatial ...
2022年9月1日 · Abstract. A central problem in spatial transcriptomics is detecting differentially expressed (DE) genes within cell types across tissue context. Challenges to learning DE include changing...
Bayesian estimation of cell type-specific gene expression with prior ...
PMCID: PMC8494232. DOI: 10.1101/gr.268722.120. Abstract. When assessed over a large number of samples, bulk RNA sequencing provides reliable data for gene expression at the tissue level. Single-cell RNA sequencing (scRNA-seq) deepens those analyses by evaluating gene expression at the cellular level.
Cell type-specific genetic regulation of gene expression
2020年9月11日 · The Genotype-Tissue Expression (GTEx) project has identified expression and splicing quantitative trait loci in cis (QTLs) for the majority of genes across a wide range of human tissues. However, the functional characterization of these QTLs has been limited by the heterogeneous cellular composition of GTEx tissue samples.
Atlas of primary cell-type-specific sequence models of gene expression ...
2023年9月25日 · To address the problem of linking these variants to expression changes in primary human cells, we introduce ExPectoSC, an atlas of modular deep-learning-based models for predicting cell-type-specific gene expression directly from sequence.
Asymmetric gene expression and cell-type-specific regulatory …
2023年4月4日 · Asymmetric gene expression and cell-type-specific regulatory networks in the root of bread wheat revealed by single-cell multiomics analysis. Lihua Zhang, Chao He, Yuting Lai, Yating Wang, Lu Kang, Ankui Liu, Caixia Lan, Handong Su, Yuwen Gao, Zeqing Li, Fang Yang, Qiang Li, Hailiang Mao, Dijun Chen, Wei Chen, Kerstin Kaufmann & Wenhao Yan.
Deciphering Cell-Type-Specific Gene Expression Signatures of …
2022年2月18日 · Moreover, through cell-type-specific differential gene expression and pathway enrichment analysis, we observed a series of signaling pathways that mapped to specific cell type in diseases, like MAPK and EGFR1 signaling pathways in fibroblasts in myocardial infarction.
Cell type specific genetic regulation of gene expression across …
Cell type specific genetic regulation of gene expression across human tissues. Sarah Kim-Hellmuth. 1 Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany. 2 New York Genome Center, New York, NY, USA. 3 Department of Systems Biology, Columbia University, New York, NY, USA.
- 某些结果已被删除