Microglia in neuropathic pain: cellular and molecular ... - Nature
2018年2月8日 · Activated microglia in the dorsal horn of the spinal cord are necessary for synaptic alterations in this region and pain hypersensitivity after nerve injury. Microglia also become activated...
Neuropeptides and Microglial Activation in Inflammation, Pain, …
We have selected neuropeptides for which microglial cells are known to express specific receptors (Table 1), which might therefore directly affect microglial activity and influence processes such as inflammation, neurodegeneration, and pain sensitivity.
Microglia in Pain: Detrimental and protective roles in …
While the majority of studies on microglia and brain diseases focus on how microglia effect synaptic pruning and neurodegeneration, pain researchers searched for neuromodulators produced by microglia that can rapidly modulate synaptic plasticity, a driving force for the pathogenesis of pain after tissue and nerve injury (Luo et al., 2014; Woolf ...
Review Microglia in Pain: Detrimental and Protective Roles in ...
2018年12月19日 · In particular, we present a balanced view of microglia, in which microglia are both detrimental and protective in their effects, contributing to both the pathogenesis and resolution of pain. Microglia Regulate Neuropathic Pain after Peripheral Nerve Injury
Microglia: sculptors of neuropathic pain? - PMC - National Center …
2020年6月17日 · In this review, we aim to explore the evidence for microglia in sculpting nervous system structure and function, as well as their important role in neuropathic pain, and finally integrate these studies to synthesize a new model for microglia in somatosensory circuit remodelling, composed of six key and inter-related mechanisms.
Role of macrophages and activated microglia in neuropathic pain ...
2019年10月30日 · Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia. 45, 89–95 (2004).
Microglia in neuropathic pain: cellular and molecular ... - PubMed
It is also becoming clear that microglia have active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Recent advances in the development of new drugs targeting microglia and the establishment of new sources of human microglia-like cells may facilitate translation of these findings from bench to bedside.
Microglia in Pain: Detrimental and Protective Roles in …
The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain.
A Fatal Alliance between Microglia, Inflammasomes, and Central Pain
2020年5月26日 · During development, microglia play an active role in the development, plasticity, maintenance, and pruning of synapses [ 4 ]. This enables microglia to influence nerve cell survival and to shape neural networks. In the adult brain, they fulfill several immunological functions.
Mechanisms and Therapeutic Prospects of Microglia-Astrocyte
2024年10月29日 · Neuropathic pain is a prevalent and debilitating condition experienced by the majority of individuals with spinal cord injury (SCI). The complex pathophysiology of neuropathic pain, involving continuous activation of microglia and astrocytes, reactive gliosis, and altered neuronal plasticity, poses significant challenges for effective treatment.
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