The 2‐Pyridyl Problem: Challenging Nucleophiles in …
This Review focuses on the methods developed for the challenging coupling of 2-pyridine nucleophiles with (hetero)aryl electrophiles, and ranges from traditional cross-coupling processes to alternative nucleophilic reagents and novel main group approaches.
The 2‐Pyridyl Problem: Challenging Nucleophiles in …
Despite the clear importance of pyridines, their functionalisation remains challenging, particularly at the 2‐position. In transition‐metal‐catalysed coupling chemistry, the use of 2‐pyridyl derivatives as nucleophilic coupling partners has proved notoriously …
Recent advances in chemistry and pharmacological aspects of 2 …
2021年6月1日 · The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance. Furthermore, 2-pyridones are a different category of pharmacophores that exhibit several biological activities.
2-Pyridyl Group - an overview | ScienceDirect Topics
We show the recent examples of them. Lv, Zhang, and coworkers reported AH of 2-pyridyl ketones with a catalytic system of [Rh(cod)](BF 4) and BINAPINE with excellent enantioselectivity (Scheme 28). 74 In this case, 2-pyridyl group was precisely differentiated not
Selection of boron reagents for Suzuki–Miyaura coupling
Due to their increased stability, pinacol boronic esters can be used in SM couplings as replacements for unstable boronic acids. One of the most infamous examples is the 2-pyridyl moiety, because its decomposition via protodeboronation can be very rapid indeed.
A General Solution for the 2-Pyridyl Problem - Wiley Online …
2012年1月27日 · Problem solved: An air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades.
A general solution for the 2-pyridyl problem - PubMed
2012年3月12日 · Problem solved: an air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu (DEA) (2) powerfully enables palladium-mediated cross-couplings with air-stable boronates 1 ….
The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling ...
2020年11月17日 · This Review focuses on the methods developed for the challenging coupling of 2‐pyridine nucleophiles with (hetero)aryl electrophiles, and ranges from traditional cross‐coupling processes to ...
Diversity-oriented functionalization of 2-pyridones and uracils
2021年5月20日 · 2-Pyridone is an important class of electron-deficient heterocycle, widely found in bioactive natural products (Fig. 1A) 1, 2, 3, 4, eg. (−)-maximiscin, (+)-hosieine A, and (+)-lyconadin A....
formation of unsymmetrical 2,2’-bis-pyridines are scarce. This Review focuses on the methods developed for the challenging coupling of 2-pyridine nucleophiles with (hetero)aryl electrophiles, and ranges from traditional cross-coupling processes to alternative nucleophilic reagents and novel main group approaches. 1.