Tumor antigen - Wikipedia
Mutation of protooncogenes and tumor suppressors which lead to abnormal protein production are the cause of the tumor and thus such abnormal proteins are called tumor-specific antigens. Examples of tumor-specific antigens include the abnormal products of ras and p53 genes.
Tumor Antigens - Tumor Antigens - Merck Manual Professional Edition
Many tumor cells produce cancer-associated or cancer-specific molecules, usually peptides, which may be released in the blood or displayed on the cell surface. Any molecule capable of being recognized by the immune system and triggering an immune response is …
Uncovering the Tumor Antigen Landscape: What to Know about …
Tumor antigens can generally be categorized into tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs) based on the expression pattern of the parental gene.
Antigen presentation in cancer: insights into tumour ... - Nature
2021年3月9日 · Indeed, studies suggest that tumours have developed various means to limit HLA-I presentation of antigens and evade immune recognition. Cancer rejection antigens are the targets of...
Tumor Antigens - Holland-Frei Cancer Medicine - NCBI Bookshelf
For something to be a tumor antigen, it must be recognized by specific immune effector cells and/or antibodies and be produced by tumor cells. Among the tumor antigens, some may be tumor specific while others may also be expressed by normal tissues.
Tumor Antigen - an overview | ScienceDirect Topics
There are various categories for tumor antigens and they are generally classified into tumor associated antigens (TAA) and tumor specific antigens (TSA). TAAs are normally expressed in healthy tissues but overexpressed or posttranslationally altered in malignant tissues.
Antigen presentation in cancer — mechanisms and clinical
2023年6月16日 · We survey the biological processes regulating the antigen-presentation machinery (APM) in cancer and discuss how these processes modulate immunopeptide processing and presentation to T cells.
Identification of tumor antigens with immunopeptidomics
2021年10月11日 · In this Review, we describe canonical and noncanonical tumor antigens and discuss the importance of noncanonical antigens in recognition of tumors by the immune system and, potentially, in...
Personal tumor antigens in blood malignancies: genomics …
As reviewed below, strategies that enable targeting of these novel antigens can be achieved using whole-tumor, DC, and personal antigen–specific vaccines. Whole tumor cell vaccines have the advantage of providing a broad repertoire of tumor candidate antigens, including neoantigens, and have been tested over the past two decades.
Tumor Antigens - SpringerLink
2017年1月1日 · Tumor antigens (TAs) are antigens recognized by specific immune effector cells and/or antibodies and differentially expressed (qualitatively and/or quantitatively) in the tumor tissue as compared to the normal counterpart tissue.