T helper cell - Wikipedia
Mature T h cells express the surface protein CD4 and are referred to as CD4+ T cells. CD4 + T cells are generally treated as having a pre-defined role as helper T cells within the immune …
Recent advances in understanding the Th1/Th2 effector choice
In this review, we will discuss some recent interesting advances towards understanding the Th1/Th2 effector cell “choice”, particularly during in vivo immune responses, which include the …
Regulation and Function of Proinflammatory TH17 Cells - PMC
In addition to TH1 and TH2 cells, a third subset of effector TH cells has recently been described and termed TH17. Since their identification, TH17 cells have emerged as crucial players in …
Th1 and Th17 cells: Adversaries and collaborators - PMC
Identification of the IL-17-producing CD4 + effector cell lineage (Th17) has helped shed light on this issue. Th17 effector cells are induced in parallel to Th1, and, like Th1, polarized Th17 cells …
Frontiers | Distinct spatial and temporal roles for Th1, Th2, and Th17 ...
2022年8月11日 · In this review, we will discuss the kinetics of the Th1, Th2, and Th17 immune responses incorporating temporal and spatial cues in the context of asthma.
One road to the TH17 pathway: how TH1 led to TH17 (and vice …
2020年7月2日 · Casey Weaver recounts how his group’s discovery of the T H 17 pathway resolved several conundrums that had arisen in the wake of the original T H 1–T H 2 hypothesis.
Defining the TH17 cell lineage | Nature Reviews Immunology
2021年9月27日 · CD4 + T helper (T H) cells produce cytokines to regulate immune responses; T H 1 cells and T H 2 cells, which were discovered in the 1980s, have important roles in …
Recent advances in understanding the Th1/Th2 effector choice
2021年3月15日 · In this review, we will discuss the recent advances in the field, focusing on some new players in the transcriptional network, contributions of DCs and ILCs, and alternative …
The T reg /Th17 Cell Balance: A New Paradigm for Autoimmunity …
Regulatory T cells and T helper 17 cells are two recently described lymphocyte subsets with opposing actions. In this review, we discuss the mechanisms that promote development of …
Interleukin-17 and Type 17 Helper T Cells | NEJM - New …
2009年8月27日 · They named these lymphocytes type 1 helper T cells (Th1 cells) and type 2 helper T cells (Th2 cells). 1 Th1 cells produce large quantities of interferon-γ, induce delayed …