DNA damage response signaling pathways and targets for …
2020年5月1日 · DNA double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses (DDRs), including those …
A new wave of innovations within the DNA damage response
2023年9月8日 · In this review, we revisited the progress of DDR targeting therapy beyond the launched first-generation PARP inhibitors. Next generation PARP1 selective inhibitors, which …
Exploring the role of PARP1 inhibition in enhancing antibody–drug ...
16 小时之前 · The introduction of antibody–drug conjugates represents a significant advancement in targeted therapy of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). …
Making drugs from T cells: The quantitative pharmacology of
2024年3月18日 · Genetically engineered T cells have proven highly efficacious in treating B cell malignancies, generating durable tumor responses and even cures with a single dose. Six …
Exposure–Response Relationships of Anticancer Agents
2013年11月30日 · The understanding of the exposure-associated target response in early development allows for selection of optimum dose and/or dosing regimen for pivotal efficacy …
Antibody-drug conjugates as targeted therapies: Are we there …
2020年12月1日 · Antibody-drug conjugates (ADCs) are targeted therapies with the expectation of broadened therapeutic window due to tumor-specific drug delivery. Recent approvals, …
Characterizing Exposure–Response Relationship for Therapeutic ...
2020年6月18日 · Recent data from immuno-oncology clinical studies have shown the exposure–response (E–R) relationship for therapeutic monoclonal antibodies (mAbs) was …
Translating CD47-Targeted Therapy in Gastrointestinal Cancers: …
1 天前 · This review presents a thorough investigation of the role of CD47 in gastrointestinal cancers. We performed a comprehensive, in-depth review of over 100 preclinical and clinical …
Developing Exposure/Response Models for Anticancer Drug …
2015年1月21日 · Exposure-response modeling can include TTE models and models relating exposure to adverse events. Such models can be applied to investigate DDI. Simulation can …
Characterizing Exposure-Response Relationship for …
Recent data from immuno-oncology clinical studies have shown the exposure-response (E-R) relationship for therapeutic monoclonal antibodies (mAbs) was often confounded by various …