Defining ‘T cell exhaustion’ | Nature Reviews Immunology
2019年9月30日 · ‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more...
T cell exhaustion - Nature Immunology
2011年5月18日 · T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors...
T-cell exhaustion: characteristics, causes and conversion - PMC
T-cell exhaustion is characterized by the stepwise and progressive loss of T-cell functions and can culminate in the physical deletion of the responding cells. Exhaustion is well-defined during chronic lymphocytic choriomeningitis virus infection ...
T cell exhaustion - PubMed
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells.
Molecular and cellular insights into T cell exhaustion
2015年7月24日 · Here, we review recent advances that provide a clearer molecular understanding of T cell exhaustion and reveal new therapeutic targets for persisting infections and cancer.
Defining 'T cell exhaustion' - PubMed
'T cell exhaustion' is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours.
Mechanisms of T cell exhaustion guiding next generation …
T cell exhaustion is a cell fate decision that limits the efficacy of immunotherapy. T cell-based immunotherapy approaches need to be applied prior to terminal exhaustion. Strategies to epigenetically reprogram T cells can redirect their developmental fate resulting in …
T Cell Exhaustion - PubMed
Here we review the process of T cell exhaustion, detailing the key characteristics and drivers as well as highlighting our current understanding of the underlying transcriptional and epigenetic programming.
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Acute viral infection or vaccination generates highly functional memory CD8 T cells following the Ag resolution. In contrast, persistent antigenic stimulation in chronic viral infection and cancer leads to a state of T-cell dysfunction termed T-cell exhaustion. We and other have recently identified a novel subset of exhausted CD8 T cells that ...
Cellular and molecular waypoints along the path of T cell exhaustion …
2023年9月1日 · In this review, we will summarize recent advances in understanding the cellular and molecular mechanisms modulating distinct developmental stages of T cell exhaustion in chronic viral infection and cancer. Then, we will discuss the therapeutic obstacles and opportunities for targeting T cell exhaustion in cancer. Fig. 1.