Sphingomyelin - Wikipedia
The synthesis of sphingomyelin involves the enzymatic transfer of a phosphocholine from phosphatidylcholine to a ceramide. The first committed step of sphingomyelin synthesis …
An overview of sphingolipid metabolism: from synthesis to …
By discussing the synthesis and the catabolism of mammalian sphingolipids we hope to bring to light an understanding of sphingolipids, how sphingolipids are created and destroyed, and to …
Cryo-EM structure of human sphingomyelin synthase and its …
2024年2月22日 · Sphingomyelin (SM) has key roles in modulating mammalian membrane properties and serves as an important pool for bioactive molecules. SM biosynthesis is …
21.4: Biosynthesis of Membrane Sphingolipids - Biology LibreTexts
Sphingomyelin synthesis is regulated in part by phosphatidylinositide metabolism and is connected to sterol homeostasis through the oxysterol binding protein (OSBP). SMS2 in the …
Role and Function of Sphingomyelin Biosynthesis in the …
2018年1月1日 · Sphingomyelin (SM) biosynthesis represents a complex, finely regulated process, mostly occurring in vertebrates. It is intimately linked to lipid transport and it is ultimately …
Regulation of cellular and systemic sphingolipid homeostasis
2024年6月18日 · In this Review, we discuss recent advances in sphingolipid pathways in different organelles, how secreted sphingolipid mediators modulate physiology and disease, progress …
Sphingolipids and their metabolism in physiology and disease
2017年11月22日 · Sphingomyelin synthase-related (SMSr) was identified as a homologue of SMS but with much reduced activity and with a preference for utilizing phosphatidylethanolamine as …
Sphingomyelin synthase family and phospholipase Cs - PMC
Sphingomyelin (SM) biosynthesis occurs via the actions of serine palmitoyltransferase (SPT), 3 ketosphinganine reductase, ceramide synthase, and dihydroceramide desaturase to produce …
Sphingomyelin - an overview | ScienceDirect Topics
Sphingolipid synthesis is initiated by serine palmitoyltransferase (SPT), which catalyzes the condensation of palmitoyl-CoA (acyl) with serine to form 3-dihydrosphin-ganine. Further …
Methods to Characterize Synthesis and Degradation of Sphingomyelin …
This chapter will discuss methods for analyses of the rates of sphingomyelin synthesis and turnover associated with lipid rafts or plasma membrane. These methods involve the use of …