Metastatic small cell lung cancer: Symptoms, spread, and more
2022年6月29日 · Small cell lung cancer (SCLC) is the least common type of lung cancer, comprising only 15% of all cases. This type of lung cancer tends to grow rapidly and spread early, making it more resistant ...
Small-cell lung cancer: what we know, what we need to know and ... - Nature
2017年12月1日 · Small-cell lung cancer (SCLC) is a highly aggressive, lethal and widely metastatic lung cancer that kills an estimated 250,000 people worldwide yearly (based on SCLC having a 15% global lung ...
Small Cell Lung Cancer: Symptoms, Causes & Treatment - Cleveland Clinic
The cancer stage: Healthcare providers have more success treating small cell lung cancer that hasn’t spread from where it started. Treatment options: Surgery to remove tumor is an option for 1 in 20 people with limited stage small cell lung cancer. People who can’t have surgery may receive chemotherapy and radiation therapy.
Current Diagnosis and Management of Small-Cell Lung Cancer
2019年8月2日 · Small-cell lung cancer (SCLC) is an aggressive disease with distinct pathological, clinical, and molecular characteristics from non–small-cell lung cancer. SCLC has high metastatic potential, resulting in a clinically poor prognosis. Early concurrent chemo-radiation is the standard of care for limited-stage SCLC (LS-SCLC). Prophylactic cranial irradiation (PCI) is …
Specific organ metastases and survival in small cell lung cancer
2012年7月9日 · Discussion. The incidence of distant metastasis at the time of initial diagnosis of SCLC in this study was 60.6%, and the most common metastatic sites were the liver, bone, brain, lung and adrenal glands. In this study, we examined whether specific organ metastasis at the time of presentation had prognostic significance in SCLC patients.
Mechanisms of small cell lung cancer metastasis - PMC
Abstract. Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, small cell lung cancer (SCLC) has remarkable metastatic proclivity, with a majority of patients ...
Small Cell Lung Cancer - StatPearls - NCBI Bookshelf
2023年7月10日 · Lung cancer is the second most diagnosed cancer in the United States. It is the leading cause of cancer death in both men and women, accounting for approximately a quarter of all cancer deaths. Lung cancer is histologically divided into 2 main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). SCLC comprises about 15% of lung cancer while NSCLC comprises approximately ...
Signatures of plasticity, metastasis, and immunosuppression in …
2021年11月8日 · Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). ... Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer Cancer Cell. 2021 Nov 8;39(11):1479-1496.e18. doi: 10. ...
Mechanisms of small cell lung cancer metastasis - PubMed
2021年1月11日 · Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, small cell lung cancer (SCLC) has remarkable metastatic procliv …
Small-cell lung cancer | Nature Reviews Disease Primers
2021年1月14日 · Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by an exceptionally high proliferative rate, strong predilection for early metastasis and poor prognosis. SCLC ...