reaction mechanism - Reductive amination in case of secondary …
2019年7月25日 · Reductive amination in case of secondary amines. When an aldehyde or a ketone undergoes reductive amination when a primary amine is acting,the mechanism follows …
Why adding sodium bicarbonate quenches a reductive amination …
2022年2月13日 · According to Grice et al. [], the addition of the bicarbonate anions to the reaction mixture containing excess sodium triacetoxyborohydride and acetic acid may trigger an attack …
organic chemistry - Reductive amination of (protected) 3 ...
2014年10月30日 · I agree for product 1. For product 2, if you go for the intramolecular route then the product of a reductive amination should be azetidine. The 2nd step of your mechanism in …
Reduction of oximes with lithium aluminium hydride
2017年1月9日 · Add a comment. Comprehensive Organic Synthesis, 2nd ed. writes (emphasis mine) 1. The reaction involves reduction of C=N bond and reductive cleavage of N–O bond. I …
Mechanism for reductive and oxidative "ozonide" workup
2024年9月8日 · $\begingroup$ Oxidative workup mechanism Sir, herein the mechanism listed from "step 5" onwards is different as compared to the "scheme 2" mechanism provided by you. …
Synthesis question: Using reductive amination to form pyrrolidine
2020年7月30日 · What molecule results from treating 4-oxopentanal with $\\ce{NH4Cl}$ and $\\ce{NaCNBH3}$? Why? Is this a good, high yield reaction? I believe that pyrrolidine is …
Role of methanol in NaBH4 reduction - Chemistry Stack Exchange
2017年8月1日 · MeOH does react with NaBH4 but that reaction is slow at ice-bath temperature and the reaction with carbonyls is faster. whenever we mix NaBH4 and MeOH gas bubbles …
stereochemistry - How does Walter White make pure crystal meth …
Racemic methamphetamine was obtained by the Winnebago-based chemists by reductive amination of P2P using methylamine and hydrogen over activated aluminum. While his blue …
organic chemistry - Reaction mechanism of imine reduction to …
2015年10月16日 · The mechanism is electron transfer. The imine will take one electron from metal to form a radical anion ($\ce{.CR2-NR'^{-}}$) intermediate; the $\ce{-NR'^{-}}$ will grab …
organic chemistry - Reduction of α,β-unsaturated nitro …
These ketones can be converted to primary amines by reductive amination in methanol (or ethanol) in the presence of (excess) ammonia and, of course, hydrogen over Raney Nickel or …