Fluoxetine: Uses, Interactions, Mechanism of Action
Mechanism of action The monoaminergic hypothesis of depression emerged in 1965 and linked depression with dysfunction of neurotransmitters such as noradrenaline and serotonin. 13 Indeed, low levels of serotonin have been observed in the cerebrospinal fluid of patients diagnosed with depression. 3 As a result of this hypothesis, drugs that ...
Fluoxetine - Wikipedia
Fluoxetine, sold under the brand name Prozac, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [2] . It is used for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), anxiety, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. [2] .
FLUoxetine: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Mechanism of Action Inhibits CNS neuron serotonin reuptake; minimal or no effect on reuptake of norepinephrine or dopamine; does not significantly bind to alpha-adrenergic, histamine, or cholinergic receptors
Fluoxetine - Uses, Side Effects, and More - WebMD
2024年4月24日 · How does fluoxetine work (mechanism of action)? Fluoxetine is an antidepressant that belongs to a group of medicines called serotonin selective reuptake inhibitors (SSRIs).
Fluoxetine (Prozac) - PsychDB
2021年3月6日 · Fluoxetine (Trade name: Prozac) is an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class commonly used in the treatment of major depressive disorder, anxiety disorders, and eating disorders.
Fluoxetine - SpringerLink
2021年1月1日 · Mechanisms of Action Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). Normally, serotonin is released from the presynaptic axon terminal to travel across the synaptic cleft and attach to the postsynaptic axon terminal.
(S)-Fluoxetine: Uses, Interactions, Mechanism of Action
2010年9月15日 · An N-methyl-3-phenyl-3- [4- (trifluoromethyl)phenoxy]propan-1-amine that has S configuration (the antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine).
Clinical Pharmacology and Pharmacokinetics of Fluoxetine: A …
2018年8月6日 · After a lead compound which possesses desirable pharmacological properties is found, through the exhaustive screening of a variety of compounds, a number of congeners are then synthesised and tested, using specific physiological or …
Early antidepressant medications—tricyclic antidepressants (TCAs) and monoamine oxidase inhibi-tors (MAOIs)—were discovered through astute clinical observations. These first-generation medica-tions were effective because they enhanced …
First and foremost is the fact that drugs synthesized to selectively block 5-HT (i.e., selective serotonin reup-take inhibitors [SSRIs]) or norepinephrine reuptake (i.e., norepinephrine reuptake inhibitors [NRIs]) are effective in the treatment of major depression.
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