Exploring the Versatility of the Covalent Thiol–Alkyne Reaction …
Bottom-up mass spectrometric analysis of the covalent adduct with a deuterated propargyl ABP provides mechanistic understanding of the in situ thiol–alkyne reaction, identifying the alkyne rather than an allenic intermediate as the reactive species. Furthermore, kinetic analysis revealed that introduction of (bulky/electron-donating) methyl ...
Asymmetric O -propargylation of secondary aliphatic alcohols
2020年6月1日 · Here, we report the development of a base-free, Cu-catalysed propargylic substitution reaction that enables the efficient, asymmetric O -propargylation of secondary aliphatic alcohols.
Propargylic Substitution - Organic Chemistry Portal
A general and efficient FeCl 3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, forms new C-C, C-O, C-S and C-N bonds.
Two-stage thiol-based click reactions for the preparation and …
In the first stage, two self-adhesive hydrogels (HG-1 and HG-2) were constructed via the thiol-based click reactions and thiol–thiol coupling reaction under different stimuli, employing the same functional copolymer poly (propargyl methacrylate- co-N - (3,4-dihydroxyphenethyl) methacrylamide- co -poly (ethylene glycol) methyl ether methacrylate)...
Thiol-yne ‘click’/coupling chemistry and recent ... - ScienceDirect
2014年10月23日 · In this study the substrates of choice, N-allyl and N-propargyl maleimides, contained highly electron deficient C C bonds as well as alkene/alkyne groups typically exploited in radical thiol-ene and thiol-yne reactions.
Synthetic Approaches to Combine the Versatility of the Thiol …
2019年6月5日 · Thiol chemistry is an efficient tool to manipulate the microstructure of aliphatic polyesters and open the way to different applications. Synthetic strategies that aim to synthesize thiol-functionalized aliphatic polyesters are reviewed herein.
Glycosylation of the polypropylene membrane surface via thiol–yne …
2013年10月1日 · First, alkyne-functionalized membrane surface was fabricated by plasma pretreatment combined with UV-induced graft polymerization of 3-(trimethylsilyl) propargyl methacrylate. Then, the glycosylated membrane surface was directly fabricated with the thiol–yne click reaction to ensure rapid process, improved efficiency, and high glycosyl density.
Exploring the Versatility of the Covalent Thiol-Alkyne ... - PubMed
2021年5月5日 · Bottom-up mass spectrometric analysis of the covalent adduct with a deuterated propargyl ABP provides mechanistic understanding of the in situ thiol-alkyne reaction, identifying the alkyne rather than an allenic intermediate as the reactive species.
Renewable Thiol–yne “Click” Networks Based on Propargylated …
2022年3月11日 · Thanks to the derivatization with propargyl groups, lignin fractions can be thermally cross-linked using a thiol–yne chemistry approach. In this study, a set of thermosets was synthesized with tetrafunctional thiol, PETMP, used as a cross-linker, and varying amounts of the reactive diluent, P-4MS ( Scheme 1 ).
Exploring the Versatility of the Covalent Thiol–Alkyne Reaction …
2021年5月5日 · Bottom-up mass spectrometric analysis of the covalent adduct with a deuterated propargyl ABP provides mechanistic understanding of the in situ thiol–alkyne reaction, identifying the alkyne rather than an allenic intermediate as the reactive species.