Phosphine oxide - Wikipedia
Phosphine oxide is the inorganic compound with the formula H 3 PO. Although stable as a dilute gas, liquid or solid samples are unstable. Unlike many other compounds of the type PO x H y, H 3 PO is rarely discussed and is not even mentioned in major sources on main group chemistry. [1]
Phosphine oxides - Wikipedia
Phosphine oxides are phosphorus compounds with the formula OPX 3. When X = alkyl or aryl, these are organophosphine oxides. Triphenylphosphine oxide is an example. An inorganic phosphine oxide is phosphoryl chloride (POCl 3). [1] The parent phosphine oxide (H 3 PO) remains rare and obscure.
The Wittig reaction cleans up | Nature Chemistry
For over 50 years, the preferred method used by synthetic organic chemists for making alkenes has been the Wittig reaction 1. The reaction involves the condensation of a carbon–phosphorus ylide...
Phosphine Oxide - an overview | ScienceDirect Topics
Primary phosphine oxides can be prepared via the reaction of phosphine with ketones, which involves transfer of oxygen from carbon to phosphorus in the first step. Mixture of primary and secondary phosphine oxides was obtained reacting ketones and phosphine in …
Phosphine oxide | HOP | CID 166931 - PubChem
Phosphine oxide | HOP | CID 166931 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Phosphine oxide synthesis by substitution or addition
A nickel-catalyzed benzylic substitution of secondary phosphine oxide provides dialkylated P-stereogenic tertiary phosphine oxides with high enantioselectivities. The reaction was performed under mild conditions with commercially available benzyl chlorides and bench stable secondary phosphine oxides, exhibiting broad functional group tolerance.
Phosphine Oxides from a Medicinal Chemist’s Perspective ...
2020年6月1日 · In this account, the physicochemical and in vitro properties of phosphine oxides and related phosphorus-containing functional groups are reported and compared to more commonly used structural motifs in drug discovery.
Phosphine Oxides from a Medicinal Chemist's Perspective ...
2020年7月9日 · We demonstrate that phosphine oxides are highly polar functional groups leading to high solubility and metabolic stability but occasionally at the cost of reduced permeability. We conclude that phosphine oxides and related phosphorus-containing functional groups are valuable polar structural elements and that they deserve to be considered as a ...
Reduction of phosphine oxides to phosphines - ScienceDirect
2019年2月21日 · Organocatalysis in the reduction of phosphine oxides is possible. The digest is devoted to the most widespread reducing agents which are used for the reduction of tertiary and secondary phosphine oxides, phospholene oxides, phospholane oxides, phosphonates, phosphinates, α- and β-hydroxy and thiomethyl phosphine oxides, α-aminophosphine oxides.
Properties of Phosphorus Compounds - Chemistry LibreTexts
2023年1月23日 · Trivalent phosphorus is easily oxidized. In contrast with ammonia and amines, phosphine and its mono and dialkyl derivatives are pyrophoric, bursting into flame on contact with the oxygen in air. The affinity of trivalent phosphorus for oxygen (and sulfur) has been put to use in many reaction systems, three of which are shown here.