Peroxisome proliferator-activated receptor alpha - Wikipedia
Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. [5] .
PPARα: An emerging target of metabolic syndrome, …
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty acids and agonists like fibrates activate PPARα for its transactivative or repressive function.
Peroxisome proliferator-activated receptor - Wikipedia
The first PPAR (PPARα) was discovered in 1990 during the search for a molecular target of a group of agents then referred to as peroxisome proliferators, as they increased peroxisomal numbers in rodent liver tissue, apart from improving insulin sensitivity.
The peroxisome proliferator-activated receptor: A family of …
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ.
Integrated physiology and systems biology of PPARα
2014年7月1日 · The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARα in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARα, with a focus on liver.
PPARs: regulators of metabolism and as therapeutic targets in ...
Since PPARα is a master regulator of genes involved in lipoprotein and triglyceride metabolism, in particular β-oxidation, cellular uptake and export of fatty acids, future directions should be directed at identifying PPARα single, double or pan agonists with high selectivity and sensitivity towards these pathways while also minimizing off ...
Molecular mechanism of PPARα action and its impact on lipid …
2015年3月1日 · Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor subfamily. Many PPARα target genes are involved in fatty acid metabolism in tissues with high oxidative rates such as muscle, heart and liver.
PPAR control of metabolism and cardiovascular functions
2021年6月14日 · PPARα increases cellular fatty acid uptake, esterification and trafficking, and regulates lipoprotein metabolism genes. PPARδ stimulates lipid and glucose utilization by increasing...
PPARα: An emerging target of metabolic syndrome ... - PubMed
2022年12月16日 · Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty acids and agonists like fibrates activate PPARα for its transactivative or repressive function.
PPARα activation promotes liver progenitor cell-mediated liver ...
2023年10月25日 · Using the zebrafish model of LPC-mediated liver regeneration, Tg (fabp10a:pt-β-catenin), we present that peroxisome proliferator-activated receptor-alpha (PPARα) activation augments...