Physiological and pathological mechanisms of oocyte meiosis
2023年12月20日 · In this review, we mainly summarize the recent physiological and pathological mechanisms of oogenesis, involving homologous recombination, meiotic arrest and resumption, maternal mRNA degradation, post-translational regulation, zona pellucida assembly, and so on.
Oocyte development, meiosis and aneuploidy - PMC
This review will discuss how events that occur in foetal oocyte development and during the oocytes’ prolonged dictyate arrest can influence meiotic chromosome segregation and the incidence of aneuploidy in adult oocytes. Keywords: Oocyte, Meiosis, Aneuploidy, Trisomy, Recombination, Cohesion. 1.
Mechanisms of Oocyte Maturation and Related Epigenetic …
2021年3月18日 · Oocyte meiotic maturation is a complicated and vital process used to attain full competence required for the oocyte as well as early embryonic development. An oocyte arrested at meiotic prophase I contains a large nucleus covered by a nuclear envelope, which is known as the germinal vesicle (GV).
Regulation of the meiotic divisions of mammalian oocytes and eggs
Here, we review the cellular events that govern the passage of the oocyte through meiosis I with a focus on the role of the spindle assembly checkpoint in regulating its timing. In meiosis II, we examine how the egg achieves its arrest and how the fertilization Ca 2+ signal allows the initiation of embryo development.
KEGG PATHWAY: Oocyte meiosis - Homo sapiens (human)
The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B.
Meiosis and Fertilization - The Cell - NCBI Bookshelf
Following completion of oocyte meiosis, the fertilized egg (now called a zygote) contains two haploid nuclei (called pronuclei), one derived from each parent. In mammals, the two pronuclei then enter S phase and replicate their DNA as they migrate toward each other.
Oocyte Meiotic Maturation - ScienceDirect
2019年1月1日 · The lengthy, complex, and discontinuous meiotic process that gives rise to a mature egg is called oocyte meiotic maturation. This process encompasses four developmental programs that are essential for the production of an egg competent to undergo fertilization and embryogenesis: (1) Nuclear maturation.
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice
2024年11月8日 · Backgroud abnormalities or defects in oocyte meiosis can result in decreased oocyte quality, reduced ovarian reserve, and female diseases. However, the mechanisms of oocyte meiosis remain largely unknown, especially epigenetic regulation. Here, we explored the role of EZH1/2 (histone methyltransferase of H3K27) in mouse oocyte meiosis by inhibiting its …
Oocyte development, meiosis and aneuploidy - ScienceDirect
2015年9月1日 · This review will discuss how events that occur in foetal oocyte development and during the oocytes’ prolonged dictyate arrest can influence meiotic chromosome segregation and the incidence of aneuploidy in adult oocytes.
Function and Regulation of Histone H3 Lysine-4 Methylation …
Chromatin undergoes extensive reorganization during oocyte meiosis and fertilization, transitioning from a relatively relaxed configuration during maturation to a highly condensed state in mature eggs and returning to the interphase state after fertilization (Zhang et al., 2015). The degradation of CXXC1 is a robust means of ensuring the ...