NLRP3 - Wikipedia
NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded …
The NLRP3 inflammasome: molecular activation and regulation to ...
2019年4月29日 · NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and …
NLRP3 inflammasome: a key player in the pathogenesis of life …
2024年7月1日 · Inflammasomes are significant contributors to innate immunity, and one of the most extensively studied inflammasome complexes is NOD-like receptor 3 (NLRP3). NLRP3 …
The NLRP3 Inflammasome: An Overview of Mechanisms of
2019年7月6日 · The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 …
An update on the regulatory mechanisms of NLRP3 inflammasome ... - Nature
2021年4月13日 · In this review, we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions, …
New Insights on NLRP3 Inflammasome: Mechanisms of Activation …
2024年2月29日 · This review gives an overview of the established NLRP3 inflammasome assembly, its brief molecular mechanistic activations as well as a current update on specific …
The NLRP3 inflammasome: contributions to inflammation-related …
2023年6月27日 · The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory …
The NLRP3 inflammasome: activation and regulation
2023年4月1日 · The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, a critical component of the host innate immune system, has an important role in microbial …
Pharmacological Inhibitors of the NLRP3 Inflammasome - PMC
NLRP3 inflammasome is involved in experimental autoimmune encephalomyelitis (EAE) in animal models and multiple sclerosis (MS) in humans (40, 41). Inappropriate NLRP3 inflammasome …
The NLRP3 inflammasome: Mechanism of action, role in …
2020年12月1日 · In this review, we summarize recent advances in understanding the mechanisms of NLRP3 inflammasome activation, how dysregulation of NLRP3 inflammasome …