A small molecule BCL6 inhibitor as chemosensitizers in acute …
Oct 1, 2023 · BCL6 is a transcriptional repressor that regulates multiple genes involved in immune cell differentiation, DNA damage repair, cell cycle, and apoptosis, and is a carcinogenic factor in acute myeloid leukemia (AML).
BCOR regulates myeloid cell proliferation and differentiation
Feb 5, 2016 · As our results suggested that BCOR is implicated in suppressing myeloid cell differentiation, we compared its expression level in HL60 and NB4 cells induced to differentiate by all-trans...
Venetoclax response is enhanced by selective inhibitor of nuclear ...
Feb 11, 2020 · (A) MV-4-11, MOLM-13, and NB4 cells were treated with twofold dilutions of eltanexor, venetoclax, or their combination for 72 hours. Contour plots of synergy scores were generated from a dose matrix of eltanexor and venetoclax using the ZIP model.
Profiling protein–protein interactions to predict the efficacy of B ...
Jul 18, 2024 · B-cell-lymphoma-2 (BCL2) homology-3 (BH3) mimetics are inhibitors of protein–protein interactions (PPIs) that saturate anti-apoptotic proteins in the BCL2 family to induce apoptosis in cancer...
WK499 | BCL6抑制剂 | MCE - MCE-生物活性分子大师
BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis , cell cycle arrest and DNA damage.
WK499 | TargetMol
BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage.
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BCOR regulates myeloid cell proliferation and differentiation
Silencing of BCOR resulted in a dramatic increase in myeloid differentiation of HL60 and NB4 cells as measured by expression of CD11b (Figure 5b). All-trans retinoic acid (ATRA) was used as a positive control for inducing differentiation (Figure 5b).
The gene mutation landscape of acute myeloid leukemia cell lines …
Jan 12, 2023 · For example, the NB4 cell line carrying the t (15;17) typical of acute promyelocytic leukemia allowed to clarify the molecular mechanisms of transformation and to demonstrate the differentiation...
All-trans retinoic acid synergizes with FLT3 inhibition to eliminate ...
Jun 6, 2016 · Mechanistically, we provide evidence that the synergism of ATRA and FLT3 TKIs is at least in part due to the observation that FLT3 TKI treatment upregulates the antiapoptotic protein Bcl6, limiting the drug’s apoptotic effect.
BCL6 maintains survival and self-renewal of primary human …
Feb 11, 2021 · B-cell lymphoma 6 (BCL6) is a transcription repressor and proto-oncogene that plays a crucial role in the innate and adaptive immune system and lymphoid neoplasms. However, its role in myeloid malignancies remains unclear. Here, we explored the role of BCL6 in acute myeloid leukemia (AML).