Mitochondrial DNA variation and cancer - Nature Reviews Cancer
2021年5月27日 · Alterations in nuclear DNA-encoded mitochondrial genes have confirmed the importance of mitochondrial metabolism in cancer, affecting mitochondrial reactive oxygen species production,...
Functional Role of Mitochondrial DNA in Cancer Progression
Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metabolism. In the clinic, mtDNA variations (mutations/single nucleotide ...
Role of mitochondrial alterations in human cancer progression …
2023年7月31日 · Mitochondrial alteration-induced mitochondrial dysfunction might activate mitochondrial retrograde signaling pathways by mitochondrion-derived molecules (ROS, calcium, oncometabolites, and mtDNA) and mitochondrial stress response pathways (mtUPR and ISR) to promote cancer progression to malignancy.
Mitochondrial DNA damage, repair, and replacement in cancer
2024年10月21日 · In this review, we discuss the various forms of mtDNA damage and repair and their association with cancer initiation and progression. We also propose horizontal mitochondrial transfer as a novel mechanism for replacing damaged mtDNA.
Mitochondrial DNA damage, repair, and replacement in cancer
2024年10月21日 · In this review, we discuss the various forms of mtDNA damage and repair and their association with cancer initiation and progression. We also propose horizontal mitochondrial transfer as a novel mechanism for replacing damaged mtDNA.
Mitochondrial DNA mutations drive aerobic glycolysis to …
2024年1月29日 · Tumor mtDNA is among the most somatically mutated regions of the cancer genome, but whether these mutations impact tumor biology is debated. We engineered truncating mutations of the...
High mitochondrial DNA content is a key determinant of …
2024年10月11日 · Here, we examined the potential role of mitochondrial DNA (mtDNA) levels in conveying aggressive phenotypes in cancer cells, using two widely-used breast cell lines as model systems...
Mitochondrial DNA variation and cancer - PubMed
Alterations in nuclear DNA-encoded mitochondrial genes have confirmed the importance of mitochondrial metabolism in cancer, affecting mitochondrial reactive oxygen species production, redox state and mitochondrial intermediates that act …
Mitochondrial DNA is a major source of driver mutations in cancer
2022年8月27日 · New techniques for single-cell profiling technologies and mitochondrial genome editing overcome the key obstacles to delineating the function of mtDNA mutations in cancer. Mitochondrial DNA (mtDNA) mutations are among the most common genetic events in all tumors and directly impact metabolic homeostasis.
Mitochondrial DNA-targeted therapy: A novel approach to combat cancer …
2023年8月1日 · Mitochondrial DNA (mtDNA) encodes proteins and RNAs that are essential for mitochondrial function and cellular homeostasis, and participates in important processes of cellular bioenergetics and metabolism. Alterations in mtDNA are associated with various diseases, especially cancers, and are considered as biomarkers for some types of tumors.