Analysis of Assembly and Budding of Lujo Virus - PMC
2016年3月3日 · The family Arenaviridae is divided into Old World (OW) and New World (NW) arenaviruses on the basis of the results of geographical, serological, and phylogenetic analyses. The OW arenaviruses include Lassa virus (LASV), the causative agent of Lassa fever, which is endemic to West Africa and has been estimated to infect several hundred thousand ...
The structure of the Lujo virus spike complex | Nature …
2024年8月21日 · Lujo virus (LUJV) is a human pathogen that was the cause of a deadly hemorrhagic fever outbreak in Africa. LUJV is a divergent member of the Arenaviridae with some similarities to both the...
Genetic Detection and Characterization of Lujo Virus, a New …
2009年5月29日 · Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever–associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases).
Structural basis for receptor recognition by Lujo virus
2018年8月27日 · To uncover the structure of the receptor-binding module of LUJV, to reveal how LUJV recognizes NRP2, and to elucidate the structural differences between LUJV and the Old World and New...
Lujo病毒刺突复合物的结构,Nature Communications - X-MOL
卢霍病毒（lujv）是一种人类病原体，是非洲致命出血热爆发的原因。 lujv 是沙粒病毒科的一个不同成员，与“旧世界”和“新世界”血清群有一些相似之处，但它使用细胞进入受体神经毡蛋白-2 (nrp2)，与 ow 和 ow 的受体不同。西北病毒。
Structural basis for receptor recognition by Lujo virus
Lujo virus (LUJV) has emerged as a highly fatal human pathogen. Despite its membership among the Arenaviridae, LUJV does not classify with the known Old and New World groups of that viral family. Likewise, LUJV was recently found to use neuropilin-2 (NRP2) as a cellular receptor instead of the canon ….
The Structure of the Lujo Virus Spike Complex | bioRxiv
2024年3月13日 · Lujo virus is a human pathogen that emerged as the etiology agent of a deadly viral disease in Africa. While it is a member of the Arenaviridae, it is a distinct virus that does not classify with the classical ‘Old World’ or ‘New World’ groups of viruses in this family.
Genetic Detection and Characterization of Lujo Virus, a New
2009年5月29日 · Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever–associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases).
Structural basis for antibody-mediated neutralization of Lassa …
2017年6月2日 · The Old World family of arenaviruses contains LASV; lymphocytic choriomeningitis virus (LCMV), which causes febrile illness, neurological disease, and birth defects with a 2 to 5% seroprevalence in North America and Europe; and the 80% lethal hemorrhagic fever virus Lujo (LUJV), which emerged in Southern Africa in 2008 . …
Full article: Lujo virus: current concepts - Taylor & Francis Online
2017年12月7日 · Lujo virus (LUJV), a novel Old World arenavirus, was found to cause a fulminant viral hemorrhagic fever syndrome in an outbreak in 2008. The primary patient was from Lusaka, Zambia, and subsequent nosocomial transmission occurred to four other patients in Johannesburg, South Africa, hence the name Lujo virus.