The linear quadratic model: usage, interpretation and challenges
2018年12月19日 · The linear-quadratic model is one of the key tools in radiation biology and physics. It provides a simple relationship between cell survival and delivered dose: , and has been used extensively to analyse and predict responses to ionising radiation both in vitro and in vivo .
The alfa and beta of tumours: a review of parameters of the linear ...
2018年5月16日 · Of several radiobiological models, the linear-quadratic (LQ) model has been best validated by experimental and clinical data. Clinically, the LQ model is mainly used to estimate equivalent radiotherapy schedules (e.g. calculate the equivalent dose in 2 Gy fractions, EQD 2 ), but increasingly also to predict tumour control probability (TCP) and ...
Statistical Radiobiology - Oncology Medical Physics
Linear Quadratic Model (LQM) The linear quadratic model is the most commonly used model of cell survival used in radiation therapy. LQM is clinically useful in determining the efficacy of a given fractionation scheme.
Radiation Oncology/Radiobiology/Linear-Quadratic - Wikibooks
Linear-quadratic model. | edit source. A model which describes cell killing, both for tumor control and for normal tissue complications. Most common underlying biological rationale is that radiation produces a double strand DNA break (DSB) using a single radiation track. Individual DSB can be repaired, with first order kinetics and half-life T 1/2.
Point: The linear-quadratic model is an appropriate …
The tool most commonly used for quantitative predictions of dose / fractionation dependencies in radiotherapy is the mechanistically-based linear-quadratic (LQ) model. The LQ formalism is now almost universally used for calculating radiotherapeutic isoeffect doses for different fractionation/protraction schemes.
Mathematical models of radiation action on living cells: From …
2016年4月7日 · The Linear-Quadratic (LQ) model, which is to date the most frequently used model in radiobiology and radiotherapy, dominates all the other models by its robustness and simplicity.
The Linear Quadratic (LQ) relation between dose and the fraction of cells that survive able to form a colony after exposure to ionizing radiation (Equations 4 below) is used to report and interpret the results of radiobiological experiments.
Linear Quadratic Models - an overview | ScienceDirect Topics
The linear-quadratic model and radiobiological doses. Radiobiological dose calculation in cervical cancer treatment planning is generally based on the linear-quadratic (LQ) model (4,5). The LQ model was initially developed by both Chadwick and Leenhouts, as well as Kellerer and Rossi, independently (20,21).
Linear-quadratic (LQ) model. The most common model used today is the linear-quadratic model, where cell death as a function of dose is described by a second-order polynomial. This model assumes that there are two components to cell killing by radiation, commonly represented by two constants, α and β.
The linear-quadratic model is one of the key tools in radiation biology and physics. It provides a simple relationship between cell survival and delivered dose: S = e −αD−βD 2 , and has been used