HSF2BP protects against acute liver injury by regulating …
2022年9月27日 · Heat shock proteins (HSPs) depletion and protein misfolding are important causes of hepatocyte death and liver regeneration disorder in liver injury. HSF2BP, as its name implies, is a binding...
Inhibition of heat shock protein (molecular weight 90 kDa
Hsp90 inhibition in vivo reduces proinflammatory cytokines and prevents LPS-induced liver injury likely through repressive action of HSF1. Our results suggest a novel application for 17-DMAG in alleviating LPS-induced liver injury.
Inhibition of hsp90 attenuates pro-inflammatory cytokines and …
In this study, we targeted hsp90 to inhibit LPS signaling in the liver and reduce pro-inflammatory cytokine production preventing liver injury. Experiments performed in vivo using water-soluble and less toxic, hsp90 specific inhibitor, 17-DMAG, we show that hsp90 inhibition decreases pro-inflammatory cytokine production and alleviates LPS ...
Inhibition of heat shock protein 90 alleviates cholestatic liver injury ...
2021年1月21日 · Severe cholestatic liver injury diseases, such as obstructive jaundice and the subsequent acute obstructive cholangitis, are induced by biliary tract occlusion. Heat shock protein 90 (HSP90) inhibitors have been demonstrated to be protective for various organs.
Pharmacological Inhibition of Heat Shock Protein 90 Alleviates ...
Using murine preclinical models of acute and chronic alcoholic liver injury, we show that pharmacological inhibition of hsp90 by 17-DMAG attenuates liver injury by reducing oxidative stress, decreasing macrophage sensitization to LPS leading to diminished pro-inflammatory cytokines and amelioration of alcohol induced steatosis.
Role of HSP90 in Type 2 Diabetes Mellitus and Its ... - Springer
2024年8月20日 · The increase in HSP90 levels in alcoholic livers, and the positive effects of inhibiting it in preventing and easing alcoholic liver injury, highlight the potential of targeting HSP90 for managing liver diseases, including ALD .
Alcohol-induced Hsp90 acetylation is a novel driver of liver …
2021年8月1日 · These results indicate that Hsp90 acetylation is responsible for decreases in its interaction with eNOS and eNOS-derived NO production. AAV8-driven HDAC6 overexpression specifically in liver ECs deacetylated Hsp90, restored Hsp90’s interaction with eNOS and ameliorated alcohol-induced liver injury in mice.
Inhibition of HSP90 and activation of HSF1 diminishes …
Direct inhibition of HSP90 affects NLRP3 by reducing CASP-1 activation and subsequent IL-1β and IL-18 maturation and hence is an attractive target. Additionally, the impact of 17-DMAG to effectively ameliorate alcoholic liver injury, further demonstrates its clinical potential in ALD.
Inhibition of heat shock protein 90 alleviates cholestatic liver injury ...
2021年1月21日 · In the present study, rat models of bile duct ligation (BDL) were established, the HSP90 inhibitor 17-dimethylamino-ethylamino-17-demethoxygeldanamycin (17-DMAG) was administered, and its ability...
Effect of heat-shock protein-90 (HSP90) inhibition on human …
2010年5月1日 · Effects of HSP90 inhibition on liver regeneration and repair were determined in a murine hepatectomy model and in a model with acute carbon tetrachloride (CCl 4 )-induced liver damage. Inhibition of HSP90 effectively diminished the constitutive phosphorylation of Akt, Erk, and STAT3 in PHHs.