Hsp90 - Wikipedia
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why …
疾病治疗新视角 | “冷门” 的热休克蛋白90 - 知乎
近期，一篇发表于 Cell Death & Disease 的文章阐述了热休克蛋白 90（HSP90 ）作为多种程序性细胞死亡（PCD）常见调控节点的可能性，为众多疾病的治疗贡献了新视角。
The HSP90 chaperone machinery - Nature Reviews Molecular …
2017年4月21日 · The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells.
Hsp90: structure and function - PubMed
Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell survival, hormone and other signalling pathways. It is important for the cell's response to stress and …
Structural and functional complexity of HSP90 in cellular …
2023年7月31日 · We discuss how these HSP90 forms are shaped by post-translational modifications (PTMs), co-chaperones and other factors, and present evidence for HSP90 oligomer formation being a...
HSP90 at the hub of protein homeostasis: emerging mechanistic …
2010年6月9日 · HSP90 is one of the most abundant proteins in the cytoplasm, where it constitutes 1–2% of total protein levels 20. Some HSP90 translocates to the nucleus in response to stress and other stimuli...
The HSP90 Family: Structure, Regulation, Function, and ... - PubMed
2018年8月29日 · The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular compartments underlines their essential roles in cellular homeostasis. HSP90 and its co-chaperones orchestrate crucial physiologica …
Hsp90: Structure and Function - SpringerLink
2012年1月1日 · Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell survival, hormone and other signalling pathways. It is important for the cell’s response to stress and is a key player in maintaining cellular homeostasis.
The HSP90 Family: Structure, Regulation, Function, and ... - MDPI
2018年8月29日 · HSP90 and its co-chaperones orchestrate crucial physiological processes such as cell survival, cell cycle control, hormone signaling, and apoptosis. Conversely, HSP90, and its secreted forms, contribute to the development and progress of serious pathologies, including cancer and neurodegenerative diseases.
The HSP90 chaperone machinery - PubMed
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include ….