The effect of HIF on metabolism and immunity - Nature
2022年6月20日 · HIFA mRNA levels and/or translation can be regulated by microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and/or by angiotensin II-mediated signalling involving PI3K.
HIF-1 信号转导通路 | Cell Signaling Technology
HIF-1 会促进参与细胞自主和非自主适应缺氧的数百种基因的表达。 基因及其功能的例子可在图表中找到。 在相应蛋白水平和 mRNA 水平处，mTOR 及 STAT3 和 NF-kB 信号转导会使 HIF-α 上调。 HIF-1 会对癌细胞和基质细胞产生多效性作用。 例如，依赖于 HIF-α 的 VEGF-A 和 PDGF-B 表达会促进周皮细胞、内皮细胞和血管平滑肌细胞的增殖和迁移，从而诱导血管生成。 在癌症相关的成纤维细胞 (CAF) 中，HIF-α 介导细胞外基质 (ECM) 重构和代谢重新编程，从而支持细胞存活。
Hypoxia-inducible factor-1α is a critical transcription ... - Nature
2018年1月17日 · We show that HIF-1α transcriptionally enhances Il10 mRNA expression. In line with our results, it has been shown that both IL-21 and IL-27 induce ERK and STAT3 activation and upregulate IL-10 in...
HIF1α: A Novel Biomarker with Potential Prognostic and …
2022年7月8日 · In this study, our data suggest that the mRNA expression level of HIF1α was higher in organs such as the brain tumors, gastrointestinal tumors (esophagus, pancreas, stomach, and gallbladder), and lung tumors compared with normal tissues, both at the tissue level and the cell line level.
Diverse responses of hypoxia-inducible factor alpha mRNA
2024年10月4日 · Low dissolved oxygen (hypoxia) poses significant challenges to aquatic ecosystems, affecting the behavior, reproduction, and survival of aquatic organisms. Some fishes respond to hypoxia by changes in gene expression, which may be regulated by the hypoxia inducible factor (HIF) family of transcription factors.
周璐教授课题组报道调控HIF-1α转录活性新机制
2023年7月5日 · 通过结构优化和化学合成，获得了活性高、毒性小的探针分子HI-102；利用探针分子通过基于亲和力的蛋白质组分析技术（affinity-based protein profiling，ABPP）识别并确认其作用靶点为ATP合酶的β亚基（ATP5B）；借助敲低、敲入、荧光偏振、免疫荧光等方法进行了靶点 ...
HIF-1α pathway: role, regulation and intervention for cancer …
2015年9月1日 · HIF-1α inhibition can usually be achieved through modulation of one of the following steps: HIF-1α mRNA expression; HIF-1α protein level (protein translation or degradation); HIF-1α/HIF-1β dimerization; HIF-1α-DNA binding (HIF-1α/HRE); or HIF-1α transcriptional activity (CH-1 of p300/ C-TAD of HIF-1α).
STAT3 and HIF1α cooperatively mediate the transcriptional and ...
2023年7月5日 · For this purpose, we injected an mRNA that encodes a dominant active (DA) form of hif1αb bearing mutations at two prolines and one asparagine (P402A, P564G, N804A), hence preventing their ...
Oxidative Medicine and Cellular Longevity - Wiley Online Library
2022年7月8日 · In this study, our data suggest that the mRNA expression level of HIF1α was higher in organs such as the brain tumors, gastrointestinal tumors (esophagus, pancreas, stomach, and gallbladder), and lung tumors compared with normal tissues, both at the tissue level and the cell line level.
The transition from HIF-1 to HIF-2 during prolonged hypoxia …
2022年12月8日 · Here we demonstrate that the HIF-1 to HIF-2 transition during prolonged hypoxia is mediated by two mechanisms: (1) the HIF-1 driven increase in the glycolytic pathways that reactivates PHD activity and (2) the much less stable mRNA levels of HIF-1α (HIF1A) compared to HIF-2α (EPAS1) mRNA.