Acute respiratory distress syndrome induced by a swine 2009 H1N1 …
Mice infected with SD/09 virus showed typical ARDS symptoms characterized by 60% lethality on days 8-10 post-inoculation, highly edematous lungs, inflammatory cellular infiltration, alveolar and interstitial edema, lung hemorrhage, progressive and severe hypoxemia, and elevated levels of proinflammatory cytokines and chemokines.
Mouse Models of Acute Respiratory Distress Syndrome:
Aug 21, 2015 · Common pathophysiological indicators of ARDS in mice include impaired pulmonary gas exchange and histological evidence of inflammatory infiltrates into the lung. Thus, morphological endpoints remain a vital component of data …
Acute Respiratory Distress Syndrome Induced by a Swine 2009 H1N1 …
Jan 3, 2012 · In the present study, we used a virulent variant 2009 H1N1 virus, which was isolated from a pig and possessed a virulence-associated HA-D222G mutation, to establish an ARDS mouse model. The model established here provides a useful tool to explore the mechanism of ARDS, as well as screening and therapeutic options.
H1N1 Influenza Induced Acute Respiratory Distress Syndrome …
Sep 30, 2017 · Severe acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and ECMO has been proven to increase the survival rates in these patients by improving the gas exchange and thus preventing the further hypoxia and catecholamine induced multi-organ damage.
Serial Histopathological Examination of the Lungs of Mice ... - PLOS
Jun 20, 2011 · We examined serial pathological changes in the lungs of mice infected with influenza virus to determine the progress from viral pneumonia to ARDS/DAD. Mice were intranasally infected with influenza A/Puerto Rico/8/34 (PR8) virus, and their lungs were examined both macro- and micro-pathologically every 2 days.
Host Response Comparison of H1N1- and H5N1-Infected Mice …
In the present study, we performed a comparison of the host responses developed by mice infected by two different HP IAV: a mouse-adapted H1N1 strain and an avian H5N1 strain. We report two differential pathogenic mechanisms used by two HP IAVs, and leading to death.
Pathogenesis of influenza-induced acute respiratory distress syndrome ...
Nov 13, 2013 · Acute respiratory distress syndrome (ARDS) is a fatal complication of influenza infection. In this Review we provide an integrated model for its pathogenesis. ARDS involves damage to the epithelial–endothelial barrier, fluid leakage …
Influenza A H1N1 induces declines in alveolar gas exchange in mice ...
Aug 2, 2012 · We have shown that mice infected with a lethal dose of a mouse-adapted influenza A H1N1 viral strain develop decreased peripheral oxygen saturation, increased lung water content, and reduced alveolar fluid clearance rate, all of which are indicative, but not diagnostic of, ARDS. 12, 13 We have also found that influenza infection results in a pro...
American Journal of Respiratory Cell and Molecular Biology
We showed that the development of severe ARDS in mice infected with H1N1 influenza A virus (IAV), which occurs within 6 days post inoculation (d.p.i.), resulted in alveolar type II (ATII) epithelial cell dysfunction and altered phospholipid metabolism (3 – 6).
Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung ...
Oct 28, 2011 · Sublethal infection of mice with an H1N1 influenza virus related to that of the 1918 pandemic triggers massive airway damage followed by apparent regeneration. We show here that p63-expressing stem cells in the bronchiolar epithelium undergo rapid proliferation after infection and radiate to interbronchiolar regions of alveolar ablation.
- Some results have been removed