Gray platelet syndrome | About the Disease | GARD - Genetic …
Gray platelet syndrome (GPS) is a rare inherited bleeding disorder characterized by platelets that have a gray appearance, severe thrombocytopenia, myelofibrosis, and splenomegaly. About 60 cases from various populations around the world have been described in the literature to date.
Gray platelet syndrome - Wikipedia
Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, [1] is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis. [2]
Gray platelet syndrome - MedlinePlus
Gray platelet syndrome is a bleeding disorder associated with abnormal platelets, which are small blood cells involved in blood clotting. People with this condition tend to bruise easily and have an increased risk of nosebleeds (epistaxis). They may also experience abnormally heavy or extended bleeding following surgery, dental work, or minor ...
Gray platelet syndrome: natural history of a large patient …
Dec 2, 2010 · Gray platelet syndrome (GPS) is an inherited bleeding disorder characterized by macrothrombocytopenia and absence of platelet α-granules resulting in typical gray platelets on peripheral smears. GPS is associated with a bleeding tendency, myelofibrosis, and splenomegaly. Reports on GPS are limited to case presentations.
Gray platelet syndrome | Blood - American Society of Hematology
Jan 10, 2013 · The name GPS comes from the gray appearance of the platelets in the peripheral blood smear as a result of the absence of α-granules. The genetic basis of GPS was recently demonstrated to be due to mutations in NBEAL2.
Gray Platelet Syndrome - American Society of Hematology
Feb 9, 2018 · Grey platelet syndrome is a rare cause of mild to moderate bleeding tendencies often diagnosed in childhood, but occasionally diagnosed later in life. It is caused by an absence of protein-containing alpha granules in both megakaryocytes and platelets resulting in large, agranular, colorless, poorly functioning platelets [1].
Orphanet: Gray platelet syndrome
Gray platelet syndrome (GPS) is a rare inherited bleeding disorder characterized by macrothrombocytopenia, myelofibrosis, splenomegaly and typical gray appearance of platelets on Wright stained peripheral blood smear.
Gray platelet syndrome - NIH Genetic Testing Registry (GTR)
The gray platelet syndrome (GPS) is a rare inherited disorder characterized by mild to moderate bleeding tendency, moderate thrombocytopenia, and a marked decrease or absence of platelet alpha-granules and of the proteins contained in alpha-granules. The platelets are enlarged, but not giant, and have a gray appearance on light microscopy of ...
gray platelet syndrome
Gray platelet syndrome (GPS) is a rare inherited bleeding disorder characterized by macrothrombocytopenia, myelofibrosis, splenomegaly and typical gray appearance of platelets on Wright stained peripheral blood smear.
Gray Platelet Syndrome - an overview | ScienceDirect Topics
Gray platelet syndrome (GPS) is a rare inherited disorder characterized by mild to moderate thrombocytopenia with bleeding tendency and a marked decrease or absence of platelet α-granules and of the proteins contained in them.