Galactose Permease (GalP), is a member of the Major Facilitator Super Family (MFS) and therefore has structural similarities to the other …

GalP is a monosaccharide transporter that uses a chemiosmotic mechanism to transport its substrates into the cytoplasm of E. coli (1). Glucose, galactose and other hexoses are transported by GalP by the use of the proton gradient produced by th…

The GalP symporter links galactose and proton import, using the favorable proton concentration gradient to move galactose against its concentration gradient. However, this mechanism, if in isolation, would result in acidification of the cytopla…

The GalP/H+ symporter is the galactose permease from the galP gene of the Escherichia coli genome. Galactose is an alternate carbon source to the preferable glucose . The cAMP/CRP catabolite repression regulator is most likely involve…

Several other symporters have been identified in E. coli and in other bacteria. E. coli has a well-studied GltS glutamate/Na+ symporter that aids in the uptake of glutamate into the cell along with an influx of sodium ions. It also has a serine-threo…

GalP is homologous to GLUT-1 found in mammalian cells (12). Both transporters are MFS transporters and possess 29% sequence identity (4). GLUT-1 is a glucose transporter present in most mammalian cells (Figure 5) (12). Its structure is nearl…