FOXO3 - Wikipedia
Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. [5] Function. FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6.
Forkhead box protein O1 - Wikipedia
Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. [5] FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to ...
FOXO family isoforms | Cell Death & Disease - Nature
2023年10月27日 · The paralogous FOXO genes encode for the FOXO isoforms FOXO1, 3, 4, and 6, here referred to as paralog-derived isoforms, and each of these single genes can generate variants of these...
FOXO3: A Major Gene for Human Longevity--A Mini-Review
Background: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3), is one of only two for which genetic polymorphisms have exhibited consistent associations with longevity in diverse human populations.
FOXO transcription factors: key regulators of cellular quality control
FOXO transcription factors are conserved regulators of longevity downstream of insulin signaling. These transcription factors integrate signals emanating from nutrient deprivation and stress stimuli to coordinate programs of genes involved in ...
Therapeutic strategies targeting FOXO transcription factors
2020年11月10日 · Delineating how specific compounds affect FOXO activity is particularly useful and can be done by evaluating FOXO localization, FOXO-driven promoter activity and FOXO target gene...
FOXO transcription factors as mediators of stress adaptation
2023年9月14日 · The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16, which gained notoriety for its...
Introduction to FOXO Biology - PubMed
Forkhead box O (FOXO) proteins are a family of transcription factors with four members in mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified as downstream regulators of the insulin pathway, are known to bind to the promoters of a broad variety of target genes and co ….
Role of FoxO transcription factors in aging and age-related …
2021年11月2日 · Here, we summarize the signaling pathways and cellular functions of FoxO proteins. We also review the complex role of FoxO in aging and age-related diseases, with focus on type 2 diabetes and Alzheimer’s disease and discuss the possibility of FoxO as a molecular link between aging and disease risks.
FOXO Transcription Factors: Their Clinical Significance and …
2014年4月3日 · FOXOs transcriptionally activate or inhibit downstream target genes, thereby playing an important role in proliferation, apoptosis, autophagy, metabolism, inflammation, differentiation, and stress resistance (Table 1). Deletion …