FOXO1 regulates developmental lymphangiogenesis by …
2020年1月17日 · These results suggest that FOXO1 serves an essential role in normal developmental lymphangiogenesis by promoting LEC migration toward CXCL12 and by regulating their proliferative activity. This study provides valuable insights into the molecular mechanisms underlying developmental lymphangiogenesis.
Downregulated Copper Homeostasis-Related Gene FOXO1 as a …
2022年6月28日 · FOXO1, a winged-helix transcription factor, regulates a lot of physiological processes such as glucose homeostasis, apoptosis, autophagy, and cell cycle control. Additionally, FOXO1 promotes the expression of metal-containing antioxidant proteins including Cu-containing proteins and plays an important role in Cu homeostasis .
CXCR4 and CXCR5 orchestrate dynamic germinal center reactions …
2019年6月3日 · In this commentary, we will discuss the roles of CXCL12-CXCR4 and CXCL13-CXCR5 pairs and related signaling pathways in guiding dynamic germinal center (GC) reactions and B cell selection and ...
Targeting CXCR4 impaired T regulatory function through PTEN in …
2024年5月4日 · FOXO1 and FOXO3 promote Foxp3 expression, upregulate CTLA-4 and other Treg-associated genes, and inhibit the expression of the inflammatory cytokine IFN-γ [57,58,59].
Forkhead transcription factors regulate expression of the …
2008年3月3日 · CXC chemokine ligand 12 (CXCL12) and its receptor, CXCR4, are critical for the process of angiogenesis, including the migration and tube formation of endothelial cells. Here we show that Foxc1 and Foxc2 directly induce CXCR4 expression by activating its promoter in endothelial cells.
SDF-1 inhibits the dedifferentiation of islet β cells in ... - PubMed
SDF-1 binds to CXCR4 to form a complex, which activates and phosphorylates AKT, subsequently increases the expression of forkhead box O1 (FOXO1), and inhibits the dedifferentiation of islet β cells. This suggests that SDF-1 may be a …
FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 ...
2020年1月17日 · These results suggest that FOXO1 serves an essential role in normal developmental lymphangiogenesis by promoting LEC migration toward CXCL12 and by regulating their proliferative activity. This study provides valuable insights into the molecular mechanisms underlying developmental lymphangiogenesis. Keywords:
FOXO1 is Required for Binding of PR on
2015年1月13日 · The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs). In this study we identified the cistrome and transcriptome of FOXO1 and its role as a transcriptional regulator of the progesterone receptor (PR).
The discrete roles of individual FOXO transcription factor family ...
2023年5月17日 · During the initial stages of B cell lineage commitment, FOXO1 enables the differentiation of common lymphoid progenitor (CLP) cells towards the pro-B cell stage. This is initiated by E2A and HeLa E-box binding (HEB) proteins, with the ablation of these proteins diminishing FOXO1 expression and inducing a block at the CLP stage (47, 48).
Remodeling of light and dark zone follicular dendritic cells governs ...
2020年5月18日 · Taken together, these data suggest that the CXCL12-dependent topological organization of LZ and DZ FDCs determines the efficacy of humoral immunity by steering the interaction of B and T cells in...
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