Hydrogels for Exosome Delivery in Biomedical Applications
Hydrogels, as hydrophilic polymer networks, can encapsulate exosomes, overcoming the issue of low tissue retention and ensuring a controlled-release platform to localize their activity. Composite exosome–hydrogel systems have been applied in fields including tissue engineering and the study of pathogenesis.
Exosome-coated oxygen nanobubble-laden hydrogel augments …
2024年4月23日 · Here, the authors show that a multifunctional exosome-coated oxygen nanobubble-laden hydrogel enhances exosome delivery and mitigates hypoxia for enhanced wound healing.
Hydrogel-exosome system in tissue engineering: A promising …
2024年8月1日 · This review has summarized the advancements made over the past decade in the research of hydrogel-exosome systems for regenerating various tissues including skin, bone, cartilage, nerves and tendons, with a focus on the methods for encapsulating and releasing exosomes within the hydrogels.
High‐Performance Hydrogel‐Encapsulated Engineered Exosomes …
2024年2月21日 · To magnify the therapeutic effects of engineered exosomes, we anticipated a hydrogel with high performance to encapsulate them for in vivo application. The ideal candidate hydrogels are expected to possess bioadhesive properties and excellent tissue integration, protecting the hydrogels from detaching from the defect site.
Exosome Loaded Protein Hydrogel for Enhanced Gelation …
2024年8月22日 · In using our hydrogel-exosome material, Q5Exo, we demonstrate the ability to use protein-based systems for encapsulation of exosomes and substantially decrease the time for wound healing in diabetic mice by topical application, showing promise for future protein-based hydrogels in wound healing applications.
Hydrogel-exosome system in tissue engineering: A promising …
2024年4月23日 · In the hydrogel-exosome system for skin tissue repair, the hydrogels are not only required to act as effective carriers for exosomes, but are also expected to possess particular functions including promoting blood clotting, tissue adhesion, antimicrobial activity, anti-inflammatory properties, and antioxidation.
A DNA-based hydrogel for exosome separation and biomedical …
2023年7月11日 · Herein, we report a DNA-based hydrogel to realize the specific and nondestructive separation of EXOs from complex biological media. The separated EXOs were directly utilized in the detection of human breast cancer in clinical samples, as well as applied in the therapeutics of myocardial infarction in rat models.
Hydrogels for Exosome Delivery in Biomedical Applications - MDPI
2022年5月24日 · Hydrogels, as hydrophilic polymer networks, can encapsulate exosomes, overcoming the issue of low tissue retention and ensuring a controlled-release platform to localize their activity. Composite exosome–hydrogel systems have been applied in fields including tissue engineering and the study of pathogenesis.
Exosome-Laden Hydrogels: A Novel Cell-free Strategy for
2022年4月1日 · In this review, we aim to outline the recent advances of exosome-laden hydrogels for in-situ bone tissue regeneration. The advantages of in-situ bone tissue engineering compared with traditional tissue engineering were summarized. Moreover, the development and challenges of hydrogels and exosomes for tissue regeneration was elaborated.
3D-exosomes laden multifunctional hydrogel enhances diabetic …
2023年11月1日 · In summary, we developed a novel multifunctional hydrogel with the characteristic of sustained release of exosomes for treating diabetic wounds. Unlike conventional exosome-loaded hydrogels, we established a 3D culture system of ADSCs to obtain 3D-Exo, which better meets clinical needs, awarding the hydrogel stronger pro-angiogenesis and anti ...