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  1. Wikipedia
    https://en.wikipedia.org/wiki/DKK1

    DKK1 - Wikipedia

    • Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-codin… 展开

    Interactions

    DKK1 has been shown to interact with LRP6 and is a high affinity ligand of Kremen proteins. 展开

    Clinical significance

    Elevated levels of DKK1 in bone marrow, plasma and peripheral blood are associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Due to the role of DKK1 in inflammation induced bone loss DKK1 … 展开

    Animal studies

    Scientists have created a DKK1 knockout model in mice that revealed the effects of this gene. All mice that were homozygous for the DKK1 knockout were dead at birth due to defects in the cranium and structures forme… 展开

    DKK1 Gene - GeneCards | DKK1 Protein | DKK1 Antibody
    DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile . Among its rela…
    GeneCards · https://www.genecards.org/cgi-bin…
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  1. 知乎专栏
    https://zhuanlan.zhihu.com/p/646187154

    DKK1：经典的Wnt/β-catenin通路拮抗剂，癌症双向调控靶点？

  2. GeneCards
    https://www.genecards.org/cgi-bin/cardd…

    DKK1 Gene - GeneCards | DKK1 Protein | DKK1 Antibody

    2024年10月1日 · DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile . Among its related pathways are ncRNAs …

  3. Nature
    https://www.nature.com/articles/1210054

    Function and biological roles of the Dickkopf family of Wnt …

  4. Nature
    https://www.nature.com/articles/1207892

    DKK1, a negative regulator of Wnt signaling, is a target …

    2004年9月20日 · Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling.

  5. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7847771

    Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the …

  6. 其他用户还问了以下问题
    Is DKK1 a protein coding gene?
    DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Alzheimer's disease and miRNA effects.

    DKK1 Gene - GeneCards | DKK1 Protein | DKK1 Antibody

    genecards.org
    What is DKK1 & dkk4?
    DKK1 is essential for embryo development and appears to be involved in various biological activities after birth. In addition to DKK1, the DKK family members include DKK2, 3, and 4. Evidence has accumulated that the DKK family members, DKK1–4, have their own functions, independently of Wnt signaling.

    Dickkopf signaling, beyond Wnt-mediated biology - ScienceDirect

    sciencedirect.com
    Is DKK1 involved in tumorigenesis?
    Dickkopf1 (DKK1) was originally identified as a secreted protein that antagonizes Wnt signaling. Although DKK1 is essential for the developmental process, its functions in postnatal and adult life are unclear. However, evidence is accumulating that DKK1 is involved in tumorigenesis in a manner unrelated to Wnt signaling.

    Dickkopf signaling, beyond Wnt-mediated biology - ScienceDirect

    sciencedirect.com
    What role does DKK1 play in colon cancer?
    Novel insights into roles for DKK1 in addition to canonical WNT signaling and the mechanism of colon cancer initiating cells transformation. Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation. DKK-1 is a potenet inhibitor of bone growth in prostate cancer-induced osteoblastic metastases.

    DKK1 dickkopf WNT signaling pathway inhibitor 1 [ (human)]

    ncbi.nlm.nih.gov
    Is DKK1 a target of the -catenin/TCF pathway?
    Correspondence to Tetsu Akiyama. Niida, A., Hiroko, T., Kasai, M. et al. DKK1, a negative regulator of Wnt signaling, is a target of the β -catenin/TCF pathway.

    DKK1, a negative regulator of Wnt signaling, is a target of the β

    nature.com
    How does DKK1 promote hepatocellular carcinoma?
    DKK1 promotes NUAK1 transcriptional expression through the activation Akt in hepatocellular carcinoma. Dickkopf-related protein 1/cytoskeleton-associated protein 4 signaling activation by Helicobacter pylori-induced activator protein-1 promotes gastric tumorigenesis via the PI3K/AKT/mTOR pathway.

    DKK1 dickkopf WNT signaling pathway inhibitor 1 [ (human)]

    ncbi.nlm.nih.gov
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  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/gene/22943

    DKK1 dickkopf WNT signaling pathway inhibitor 1 [ (human)]

  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8174842

    Dickkopf-1: A Promising Target for Cancer Immunotherapy

  9. 知乎
    https://www.zhihu.com/question/454608415

    Dickkopf相关蛋白1 (Dkk-1)是什么？ - 知乎

  10. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S1084952121002792

    Dickkopf signaling, beyond Wnt-mediated biology - ScienceDirect

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