Diltiazem | C22H26N2O4S | CID 39186 - PubChem
Diltiazem is exerts hemodynamic actions by reducing blood pressure, systemic vascular resistance, the rate-pressure product, and coronary vascular resistance while increasing coronary blood flow. Diltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparations.
Diltiazem | C22H26N2O4S - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Diltiazem, 42399-41-7, Zilden.
Diltiazem - NIST Chemistry WebBook
2016年12月10日 · CAS Registry Number: 42399-41-7. Chemical structure: This structure is also available as a 2d Mol file. Other names: Dilacor XR; Cardizem; 1,5-Benzothiazepin-4 (5H)-one, 3- (acetyloxy)-5- [2- (dimethylamino)ethyl]-2,3-dihydro-2- (4-methoxyphenyl)-, (2S-cis)-; (+)-5- [2- (Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2- (p-methoxyphenyl)-1,5 ...
Diltiazem Hydrochloride | C22H27ClN2O4S | CID 62920 - PubChem
Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility.
Crystal structures and physicochemical properties of diltiazem base …
Three molecular salts of diltiazem with aspirin, niacin and L-malic acid were synthesized and characterized by single crystal and powder XRD, DTA, solid state CP-MAS, NMR and UV/vis techniques. The single crystal structure determination allowed us to study the supramolecular structures and proton transfer interactions from the carboxylic acids ...
Diltiazem hydrochloride - DrugBank Online
Diltiazem. Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular ...
FIG. 1. Chemical structure of diltiazem with the sites of...
Diltiazem (DTZ) is a 1,5 benzothiazepine calcium channel blocker. It blocks L-type voltage-gated Ca2 + channels in vascular smooth muscle cells, in the heart and in visceral smooth muscle layers.
Chemical structures of diltiazem and two major metabolites.
Diltiazem is a calcium channel-blocking agent, efficient in treating various heart-related conditions and diseases. It has been used as a cutting agent in cocaine and prevents its common ...
diltiazem | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
2D Structure. An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor.
Diltiazem analogues: the last ten years on structure activity ...
Diltiazem and its first analogues developed in the early '70s became popular in the '80s, and were pharmacologically characterized for a long time. It is in the '90s that several research groups carried out structural variations identifying novel scaffolds for diltiazem-related compounds, with significant calcium antagonist behaviour.