Cancer cell survival depends on collagen uptake into tumor
2022年11月18日 · Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells …
The role of collagen in cancer: from bench to bedside
2019年9月14日 · Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through …
Pulling the strings of tumor collagen | Nature Cancer
2022年1月20日 · The architecture of tumor collagen greatly influences tumor biology and therapeutic response. Two new studies identify tumor DDR1 as a central player in stromal …
Cancer cells make unique form of collagen, protecting them from …
2022年7月21日 · Cancer cells produce small amounts of their own form of collagen, creating a unique extracellular matrix that affects the tumor microbiome and protects against immune …
The role of collagen in cancer: from bench to bedside - PubMed
2019年9月14日 · Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through …
Collagen code in tumor microenvironment: Functions, molecular ...
2023年10月1日 · Collagen is a major ECM component that contributes to tumor cell infiltration, expansion, and distant metastasis during cancer progression. Recent studies reported that …
Prognostic and therapeutic implications of tumor-restrictive type …
2024年10月2日 · Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor …
Immune Modulatory Properties of Collagen in Cancer
2021年12月7日 · The effects of tumor-associated collagen on immune cells could help explain why a high collagen density in tumors is often correlated with a poor prognosis. Knowledge …
Metabolic reprogramming of tumor-associated macrophages by collagen …
2022年4月11日 · In this study, we identify a role for collagen, the major constituent of tumor ECM, in the regulation of macrophage phenotype via metabolic reprogramming. This cross-talk could …
Immune Modulatory Properties of Collagen in Cancer - PubMed
2021年12月8日 · The effects of tumor-associated collagen on immune cells could help explain why a high collagen density in tumors is often correlated with a poor prognosis. Knowledge …
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