Carbamazepine-induced hyponatremia – A wakeup call - PMC
Carbamazepine is an antiepileptic agent which can cause hyponatremia, but it is rarely documented. Hyponatremia, both symptomatic and asymptomatic, has been found to be directly related to the increased mortality and morbidity of the primary disease.[ 1 ]
Management of Hyponatremia - AAFP
2004年5月15日 · Hyponatremia is an important electrolyte abnormality with the potential for significant morbidity and mortality. Common causes include medications and the syndrome of inappropriate antidiuretic...
Carbamazepine-induced hyponatremia | BJA: British Journal of ...
2016年1月20日 · The incidence of hyponatremia (Na<134 mEq/L) in 451 carbamazepine-treated patients was 13.5% and that of severe hyponatremia ((Na<128 mEq/L)) was 2.8%. [3] Advanced age was a risk factor for hyponatremia. [3]
Hyponatremia associated with carbamazepine and oxcarbazepine therapy…
One cause of hyponatremia, the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, has been associated with some drugs, including carbamazepine (CBZ). Because of its antidiuretic effects, CBZ has been used successfully to treat diabetes insipidus centralis.
A Review of Drug-Induced Hyponatremia
Hyponatremia has repeatedly been associated with carbamazepine therapy. 30-35 Carmabazepine can induce hyponatremia by increasing ADH release from the neurohypophysis.
Carbamazepine-induced hyponatremia – A wakeup call
The incidence of hyponatremia due to carbamazepine has been found to be 1.8%–40% in previous studies. Although the incidence of hyponatremia with monotherapy of carbamazepine is low, the overall incidence is on the rise.
Carbamazepine-Induced Hyponatremia: Assessment of Risk …
Hyponatremia associated with carbamazepine has been well described. The incidence ranges from 1.8% to 40% depending on the patient population studied. Severe hyponatremia in patients treated with monotherapy is uncommon.
Symptomatology of carbamazepine‐ and oxcarbazepine‐induced hyponatremia …
People with carbamazepine‐ or oxcarbazepine‐induced hyponatremia experience a 7‐fold increased risk of developing adverse symptoms during treatment. Significant predictors of adverse effects were use of oxcarbazepine (compared to carbamazepine) and number of concomitant anti‐seizure medications.
Review of carbamazepine-induced hyponatremia - ScienceDirect
1994年3月1日 · Carbamazepine (CBZ), a commonly prescribed medication in psychiatry and neurology, produces deleterious side effects with an incidence rate ranging from 33–50%; although most of these side effects are mild, transient, and reversible.
Carbamazepine-induced hyponatremia - British Journal of …
The incidence of hyponatremia (Na<134 mEq/L) in 451 carbamazepine-treated patients was 13.5% and that of severe hyponatremia ((Na<128 mEq/L)) was 2.8%. Advanced age was a risk factor for hyponatremia.