Integrin alpha M - Wikipedia
CD11b, as an integrin molecule on the surface of leukocytes, plays an important role in cell migration, adhesion, and transmigration across blood vessels, because it can bind to components of extracellular matrix and intracellular adhesion molecules (ICAMs) on the endothelial surface.
CD11b immunophenotyping identifies inflammatory profiles in …
2015年9月30日 · Altogether, these results demonstrate that increased CD11b AMΦ expression is a mouse marker of active lung inflammation with differential patterns of AMΦ CD11b upregulation and eosinophil ...
CD11b Marker for Macrophages and Microglia - Bio-Techne
CD11b is a protein on immune cells like macrophages and microglia, aiding in cell adhesion, migration, and immune response. It’s used in immune and neuro research.
Mouse Immune Cell Marker Guide | Cell Signaling Technology
Lastly, murine myeloid-derived suppressor cells (MDSCs) express high levels of CD11b, arginase, and the granulocytic marker GR1, which is itself composed of the membrane proteins Ly6C and Ly6G. In mice, MDSCs have been found in tumors as well as …
CD11b Antigen - an overview | ScienceDirect Topics
CD11b Antigen. Macrophage antigen-1 (Mac-1, CD11b/CD18, CR3) is an important member of the β2-integrin subunit, which is widely expressed on the surface of leukocytes (including neutrophils and monocytes) and affects leukocyte migration and tissue infiltration.
Overview of General and Discriminating Markers of Differential ...
2020年8月5日 · The popular microglia marker protein CD11b (also known as integrin alpha M, ITGAM; complement receptor 3 alpha, CR3A) is an alpha subunit that, along with CD18 (also named integrin beta chain-2, ITGB2), constructs an integrin complement receptor 3 (CR3, also known as macrophage 1 antigen, MAC-1).
CD11b is a therapy resistance– and minimal residual …
2010年5月6日 · A consistently increased mRNA expression of the adhesion receptor CD11b is a hallmark of the reported genomewide gene expression changes in precu.
Microglia markers - Abcam
2022年10月9日 · CD11b and CD45 A combination of CD11b and CD45 labeling can be used to distinguish microglia from macrophages. Resting microglia are CD11b hi , CD45 low , whereas macrophages are CD11b hi , CD45 hi .
Integrin CD11b activation drives anti-tumor innate immunity
2018年12月19日 · CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNA Let7a. In contrast, inhibition of CD11b prevents Let7a expression and induces cMyc...
Flow cytometric identification and cell-line establishment of ...
2019年11月29日 · We found that an anti-mouse/human CD11b antibody (clone: M1/70), also known as Mac-1, reacted to large cells (Fr. b) in the bone marrow, spleen, and PEC (Fig. 1b–d). CD11b is a marker of...